Publications of the Team

2021

Crudo F., Aichinger G., Mihajlovic J., Varga E., Dellafiora L., Warth B., Dall'Asta Ch., Berry D., Marko D., In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship, Archives of Toxicology, 2021 Apr 13, doi.org/10.1007/s00204-021-03043-x

Crudo F., Barilli A., Mena P., Maria B., Del Rio D., Dall'Asta C. Dellafiora, L., An in vitro study on the transport and phase II metabolism of the mycotoxin alternariol in combination with the structurally related gut microbial metabolite urolithin C, Toxicology Letters, 2021 Apr 1;340:15-22. doi: 10.1016/j.toxlet.2021.01.007

Oesterle I., Braun D., Berry D., Wisgrill L., Rompel A., Warth B., Polyphenol Exposure, Metabolism, and Analysis: A Global Exposomics Perspective, Annual Review of Food Science and Technology, 2021 Mar 25, doi: 10.1146/annurev-food-062220-090807

Akinyemi M. O., Ayeni K. I., Ogunremi O. R., Adeleke R. A., Oguntoyinbo F. A., Warth B., Ezekiel C. N., A review of microbes and chemical contaminants in dairy products in sub-Saharan Africa, Comprehensive Reviews in Food Science and Food Safety, 2021 Mar;20(2):1188-1220, doi: 10.1111/1541-4337.12712.

Beisl J., Varga E., Braun D., Warth B., Ehling-Schulz M., Del Favero G., Marko D., Assessing Mixture Effects of Cereulide and Deoxynivalenol on Intestinal Barrier Integrity and Uptake in Differentiated Human Caco-2 Cells, Toxins, 2021 March, DOI: 10.3390/toxins13030189

Niederstaetter L., Neuditschko B., Brunmair J., Janer L., Bileck A., Del Favero G., Gerner Ch., Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture, Biomolecules, 2021 Jan 15;11(1):113. doi: 10.3390/biom11010113.

2020

Groh I.A.M., Riva A., Braun D., Sutherland H.G., Williams O., Bakuradze T., Pahlke G., Richling E., Haupt L.M., Griffiths L.R.,  Berry D., Marko D., Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males, Antioxidants (Basel), 2020 Dec 29;10(1):E27. doi: 10.3390/antiox10010027

Meier-Menches S.M., Neuditschko B., Zappe K., Schaier M., Gerner M.C., Schmetterer K.G., Del Favero G., Bonsignore R., Cichna-Markl M., Koellensperger G., Casini A., Gerner Ch., An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells, Chemistry, 2020 Dec 1;26(67):15528-15537. doi: 10.1002/chem.202003495

Pristner M., Warth B., Drug-Exposome Interactions: The Next Frontier in Precision Medicine, Trends in Pharmacological Sciences, 2020 Dec;41(12):994-1005. doi: 10.1016/j.tips.2020.09.012.

Aichinger G., Živná N., Varga E., Crudo F., Warth B., Marko D., Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins, Mycotoxin Research, 2020 Nov. doi: 10.1007/s12550-020-00405-9.

Xue J., Guijas C., Bento H. P., Warth B., Siuzdak G., METLIN MS2 molecular standards database: a broad chemical and biological resource, nature methods, Oct. 2020, DOI: 10.1038/s41592-020-0942-5

Braun D., Eiser M., Puntscher H., Marko D., Warth B., Natural Contaminants in Infant Food: The Case of Regulated and Emerging Mycotoxins, Food Control, Oct. 2020, DOI:10.1016/j.foodcont.2020.107676

Pereira F. C., Wasmund K., Cobankovic I., Jehmlich N., Herbold C. W., Soo Lee K., Sziranyi B., Vesely C., Decker T., Stocker R., Warth B., von Bergen M., Wagner M., Berry D., Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonizatio, Nature Communications, 2020 Oct 9;11(1):5104. doi: 10.1038/s41467-020-18928-1

Crudo F., Aichinger G., Mihajlovic J., Dellafiora L., Varga E., Puntscher H., Warth B., Dall'Asta C., Berry D., Marko D., Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro, Archives of Toxicology, 2020 Oct;94(10):3541-3552. doi: 10.1007/s00204-020-02831-1.

Braun D., Schernhammer E., Marko D., Warth B., Longitudinal Assessment of Mycotoxin Co-Exposures in Exclusively Breastfed Infants, Environment International, 2020 Sept;142:105845. doi: 10.1016/j.envint.2020.105845.

Zhang Y., Liu M., Peng B., Jia S., Koh D., Wang Y., Sheng Cheng H., Soon Tan N., Warth B., Chen D., Fang M., Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems Biological Understanding of Synergism between Tris(1,3-dichloro-2-propyl)phosphate and Triphenyl Phosphate, Environmental Science and Technology, Sept. 1, 2020, DOI: 10.1021/acs.est.0c02188

Dator R., Villalta P. W., Thomson N., Jensen J., Hatsukami D. K., Stepanov I., Warth B., Balbo S., Metabolomics Profiles of Smokers from Two Ethnic Groups with Differing Lung Cancer Risk, Chemical Research in Toxicology, Aug. 17, 2020, DOI: 10.1021/acs.chemrestox.0c00064

Del Favero G., Bonifacio A., Rowland T. J., Gao Sh., Song K., Sergo V., Adler E. D., Mestroni L., Sbaizero O., Taylor M. R. G., Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes, Journal of Clinical Medicine, 2020 Jul 31;9(8):E2457. doi: 10.3390/jcm90824

Hohenbichler J., Aichinger G., Rychlik M., Del Favero G., Marko D., Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro, Biomolecules 2020, 10(7), 1018, July 9, 2020, DOI: 10.3390/biom10071018

Ezekiel Ch.N., Abia W.A., Braun D., Sarkanj B., Ayeni K.I., Qyedele O., Michael-Chikezie E.C., Ezekiel V.C., Mark B., Ahuchaogu Ch.P., Krska R., Sulyok M., Turner P., Warth B., Comprehensive mycotoxin exposure biomonitoring in breastfed and non-exclusively breastfed Nigerian children, Preprint, June 2020, DOI: 10.1101/2020.05.28.20115055

Juère E., Del Favero G., Masse F., Marko D., Popat A., Florek J., Caillard R., Kleitz F., Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: in vitro release, cytotoxicity and mitochondrial activity, European Journal of Pharmaceutics and Biopharmaceutics, 2020 June. pii: S0939-6411(20)30082-5. doi: 10.1016/j.ejpb.2020.03.015

Aichinger G., Dellafiora L., Pantazi F., Del Favero G., Galaverna G., Dall'Asta C., Marko D., Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study, Archives of Toxicology, 2020 June, doi: 10.1007/s00204-020-02746-x

Gerner M.C., Ziegler L.S., Schmidt R.L.J., Krenn M., Zimprich F., Uyanik-Ünal K., Konstantopoulou V., Derdak S., Del Favero G., Schwarzinger I., Boztug K., Schmetterer K.G., The TGF-b/SOX4 axis and ROS-driven autophagy co-mediate CD39 expression in regulatory T-cells, FASEB Journal, 2020 June, doi: 10.1096/fj.201902664

Groh I., Bakuradze T., Pahlke G., Richling E., Marko D., Consumption of Anthocyanin-Rich Beverages Affects Nrf2 and Nrf2-dependent Gene Transcription in Peripheral Lymphocytes and DNA Integrity of Healthy Volunteers, BMC Chemistry, 2020 May 29;14(1):39. doi: 10.1186/s13065-020-00690-6. eCollection 2020 Dec.

Del Favero G., Kraegeloh A., Integrating Biophysics in Toxicology, Cells, 2020 May 21;9(5):E1282. doi: 10.3390/cells9051282

Braun D., Ezekiel Ch. N., Marko D., Warth B., Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach, Frontiers in Chemistry, May 2020, DOI: 10.3389/fchem.2020.00423, eCollection2020

Juère E., Caillard R., Marko D., Del Favero G., Kleitz F., Smart protein-based formulation of dendritic mesoporous silica nanoparticles: Toward oral delivery of insulin, Chemistry, 2020 Apr. 21. doi: 10.1002/chem.202000773.

Flasch M., Bueschl Ch., Woelflingseder L., Schwartz-Zimmermann H.E., Adam G., Schuhmacher R., Marko D., Warth B. Stable isotope-assisted metabolomics for deciphering xenobiotic metabolism in mammalian cell culture, ACS Chemical Biology, 2020 Apr. 17, doi: 10.1021/acschembio.9b01016

Aichinger G., Lichtenberger F.B., Steinhauer T.N., Flörkemeier I., Del Favero G., Clement B., Marko D., The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties, Molecules. 2020 Mar 27;25(7). pii: E1524. doi: 10.3390/molecules25071524.

Del Favero G., Mayer R.M., Dellafiora L., Janker L., Niederstaetter L., Dall'Asta C., Gerner C., Marko D., Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol, Cells, 2020 Mar 31;9(4). pii: E847. doi: 10.3390/cells9040847

Beisl J., Pahlke G., Abeln H., Ehling-Schulz M., Del Favero G., Varga E., Warth B., Sulyok M., Abia W., Ezekiel CN., Marko D., Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells, Archives of Toxicology, 2020 March, doi: 10.1007/s00204-020-02658-w

Neuditschko B., Janker L., Niederstaetter L., Brunmair J., Krivanek K., Izraely S., Sagi-Assif O., Meshel T., Keppler B., Del Favero G., Witz I.P., Gerner C., The challenge of classifying metastatic cell properties by molecular profiling exemplified with cutaneous melanoma cells and their cerebral metastasis from patient derived mouse xenografts, Molecular & Cellular Proteomics, 2020 March, pii: mcp.RA119.001886. doi: 10.1074/mcp.RA119.001886

Muqaku B., Pils D., Mader J.C., Aust S., Mangold A., Muqaku L., Slany A., Del Favero G., Gerner Ch., Neutrophil extracellular trap formation correlates with improved overall survival in ovarian cancer, Cancers (Basel), 2020 Feb 21;12(2). pii: E505. doi: 10.3390/cancers12020505

Del Favero G., Hohenbichler J., Mayer R.M., Rychlik M., Marko D., Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages, Chemical Research in Toxicology, 2020 Feb, doi: 10.1021/acs.chemrestox.9b00378

Aichinger G., Pantazi F., Marko D., Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells, Toxicology Letters, Feb 2020, 13. pii: S0378-4274(19)30350-9. doi: 10.1016/j.toxlet.2019.10.025.

Puntscher H., Marko D., Warth B., First determination of the highly genotoxic fungal contaminantaltertoxin II in a naturally infested apple sample, Emerging Contaminants, Volume 6, 2020, Pages 82-86, January 2020, doi.org/10.1016/j.emcon.2020.01.002

2019

Crudo F., Varga E., Aichinger G., Galaverna G., Marko D., Dall'Asta C., Dellafiora L., Co-Occurrence and Combinatory Effects of Alternaria Mycotoxins and other Xenobiotics of Food Origin: Current Scenario and Future Perspectives, Toxins (Basel), 2019 Nov 3;11(11). pii: E640. doi: 10.3390/toxins11110640

Puntscher H., Aichinger G., Grabher S., Attakpah E., Krüger F., Tillmann K., Motschnig T., Hohenbichler J., Braun D., Plasenzotti R., Pahlke G., Höger H., Marko D., Warth B., Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats, Archives of Toxicology, 2019 Nov. doi: 10.1007/s00204-019-02575-7

Warth B. , Preindl K., Manser P., Wick P., Marko D., Buerki-Thurnherr T., Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta, Environmental Health Perspectives, 2019 Oct;127(10):107004. doi: 10.1289/EHP4860

Schmutz C., Cenk E., Marko D., The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL-1β-stimulated, Differentiated Caco-2 Cells, Molecular Nutrition & Food Research, 2019 Oct 4:e1900341. doi: 10.1002/mnfr.201900341

Aichinger G., Krüger F., Puntscher H., Preindl K., Warth B., Marko D., Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro, Archives of Toxicology, 2019 Oct. doi: 10.1007/s00204-019-02545-z

Riva A., Kuzyk O., Forsberg E., Siuzdak G., Pfann C., Herbold C., Daims H., Loy A., Warth B., Berry D., A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome, Nature Communications, 2019 Sep 25;10(1):4366. doi: 10.1038/s41467-019-12413-0.

Costa J.G., Vidovic B., Saraiva N., do Céu Costa M., Del Favero G., Marko D., Oliveira N.G., Fernandes A.S., Contaminants: a dark side of food supplements? Free Radical Research, 2019 Sep 10:1-23. doi: 10.1080/10715762.2019.1636045

Preindl K., Braun D., Aichinger G., Sieri S,, Fang M., Marko D., Warth B., A Generic Liquid Chromatography-Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices, Analytical Chemistry, 2019 Sep 3;91(17):11334-11342. doi: 10.1021/acs.analchem.9b02446

Del Favero G., Bialas F., Grabher S., Wittig A., Bräuer B., Gerthsen D., Echalier C., Kamalov M., Marko D., Becker CFW., Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus, Chemical Communications (Camb.), 2019 Aug 21;55(65):9649-9652. doi: 10.1039/c9cc02215e

Puntscher H., Cobankovic I., Marko D., Warth B., Quantitation of free and modified Alternaria mycotoxins in European food products by LC-MS/MS, Food Control, Aug 2019, DOI:10.1016/j.foodcont.2019.03.019

Gerner, M.C.; Niederstaetter, L.; Ziegler, L.; Bileck, A.; Slany, A.; Janker, L.; Schmidt, R.L.J.; Gerner, Ch.; Del Favero, G.; Schmetterer, K.G.; Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells, frontiers in pharmacology, July 10 2019, doi.org/10.3389/fphar.2019.00727

Puntscher H., Marko D., Warth B., The Fate of Altertoxin II During Tomato Processing Steps at a Laboratory Scale, Frontiers in Nutrition, 2019 Jun 13;6:92. doi: 10.3389/fnut.2019.00092. eCollection 2019

Ezekiel C.N., Sulyok M., Ogara I.M., Abia W.A., Warth B., Šarkanj B., Turner P.C., Krska R., Mycotoxins in uncooked and plate-ready household food from rural northern NigeriaAuthor links open overlay panel, Food and Chemical Toxicology, Volume 128, June 2019, Pages 171-179, doi.org/10.1016/j.fct.2019.04.002

Stadler D., Lambertini F., Woelflingseder L., Schwartz-Zimmermann H., Marko D., Suman M., Berthiller F., Krska R., The Influence of Processing Parameters on the Mitigation of Deoxynivalenol during Industrial Baking, Toxins / Basel, 2019 Jun 4;11(6). pii: E317. doi: 10.3390/toxins11060317

Woelflingseder L., Warth B., Vierheilig I., Schwartz‑Zimmermann H., Hametner C., Nagl V., Novak B., Šarkanj B., Berthiller F., Adam G., Marko D., The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol, Archives of Toxicology, 2019 Jun. doi: 10.1007/s00204-019-02459-w

Svenssen DK., Binzer SB., Medic N., Hansen PJ., Larsen TO., Varga E., Development of an Indirect Quantitation Method to Assess Ichthyotoxic B-Type Prymnesins from Prymnesium parvum, Toxins (Basel), 2019 May 4;11(5). pii: E251. doi: 10.3390/toxins11050251

Wernitznig D., Kiakos K., Del Favero G., Harrer N., Machat H., Osswald A., Jakupec M. A., Wernitznig A., Sommergruber W., Keppler B. K., First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro. Metallomics: integrated biometal science 2019 Jun 19. doi: 10.1039/c9mt00051h

Pahlke G., Attakpah E., Aichinger G., Ahlberg K., Hochkogler C.M., Schweiger K., Schipp D., Somoza V., Marko D., Dark coffee consumption protects human blood cells from spontaneous DNA damage, Journal of Functional Foods 55, Feb. 19, DOI: 10.1016/j.jff.2019.02.008

Puntscher H., Hankele S., Tillmann K., Attakpah E., Braun D., Kütt M-L., Del Favero G., Aichinger G., Pahlke G., Höger H., Marko D., Warth B., First insights into Alternaria multi-toxin in vivo metabolism, Toxicology Letters, Feb. 2019, pii: S0378-4274(18)31989-1. doi: 10.1016/j.toxlet.2018.10.006

Binzer S.B., Svenssen D.K., Daugbjerg N., Alves-de-Souza C., Pinto E., Hansen P.J., Larsen T.O., Varga E., A-, B- and C-type prymnesins are clade specific compounds and chemotaxonomic markers in Prymnesium parvum, Harmful Algae, 2019 Jan;81:10-17. doi: 10.1016/j.hal.2018.11.010

Dellafiora L., Aichinger G., Geib E., Sánchez-Barrionuevo L., Brock M., Cánovas D., Dall'Asta C., Marko D., Hybrid in silico/in vitro target fishing to assign function to "orphan" compounds of food origin - The case of the fungal metabolite atromentin, Food Chemistry, 2019 Jan 1;270:61-69. doi: 10.1016/j.foodchem.2018.07.027.

Schroeter A., Aichinger G., Stornig K., Marko D., Impact of Oxidative Metabolism on the Cytotoxic and Genotoxic Potential of Genistein in Human Colon Cancer Cells, Molecular Nutrition & Food Research, 2019 Jan;63(2):e1800635. doi: 10.1002/mnfr.201800635

Warth B., Palermo A., Rattray N.J.W., Lee N.V., Zhu Z., Hoang L.T., Cai Y., Mazurek A., Dann S., VanArsdale T., Fantin V.R., Shields D., Siuzdak G., Johnson C.H., Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells, Metbabolites, 2019 Jan 2;9(1). pii: E7. doi: 10.3390/metabo9010007.

 

2018

Del Favero G., Zaharescu R., Marko D., Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction, Archives of Toxicology, Dec. 2018, doi.org/10.1007/s00204-018-2317-6

Woelflingseder L., Del Favero G., Blažević T., Heiss E.H., Haider M., Warth B., Adam G., Marko D., Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells, Toxicology Letters, 2018 Dec.;299:104-117. doi: 10.1016/j.toxlet.2018.09.007

Braun D., Ezekiel C.N., Abia W.A., Wisgrill L., Degen G.H., Turner P.C., Marko D., Warth B., Monitoring early-life mycotoxin exposures via LC-MS/MS breast milk analysis, Analytical Chemistry, 2018 Dec., doi: 10.1021/acs.analchem.8b04576

Kollarova J., Cenk E., Schmutz C., Marko D., The mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation in THP-1 derived macrophages targeting the NF-κB signalling pathway, Archives of Toxicology, 2018 Nov, doi: 10.1007/s00204-018-2299-4

Del Favero G., Woelflingseder L., Braun D., Puntscher H., Kütt ML., Dellafiora L., Warth B., Pahlke G., Dall'Asta C., Adam G., Marko D., Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates, Toxicology Letters, 2018 Oct 1;295:424-437. doi: 10.1016/j.toxlet.2018.07.007

Aichinger G., Beisl J., Marko D., The Hop Polyphenols Xanthohumol and 8-Prenyl-Naringenin Antagonize the Estrogenic Effects of Fusarium Mycotoxins in Human Endometrial Cancer Cells, frontiers in Nutrition, 19 September 2018, doi.org/10.3389/fnut.2018.00085

Šarkanj B., Ezekiel C.N., Turner P.C., Abia W.A., Rychlik M., Krska R., Sulyok M., Warth B., Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers, Analytica Chimica Acta, Aug 17 2018, doi.org/10.1016/j.aca.2018.02.036

Del Favero G., Woelflingseder L., Janker L., Neuditschko B., Seriani S., Gallina P., Sbaizero O., Gerner C., Marko D., Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation, Scientific Reports, 2018 Jul 27;8(1):11351. doi: 10.1038/s41598-018-29728-5.

Miklosi A.G., Del Favero G., Marko D., Harkany T., Lubec G., Resolution matters: Correlating quantitative proteomics and nanoscale‐precision microscopy for reconstructing synapse identity2, Proteomics, Jul 18 2018, doi.org/10.1002/pmic.201800139

Puntscher H., Kütt M-L., Skrinjar P., Mikula H., Podlech J., Fröhlich J., Marko D., Warth B., Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins, Analytical and Bioanalytical Chemistry, 2018 Jul 18, doi: 10.1007/s00216-018-1105-8

Mastanjević K., Šarkanj B., Krska R., Sulyok M., Warth B., Mastanjević K., Šantek B., Krstanović V., From malt to wheat beer: A comprehensive multi-toxin screening, transfer assessment and its influence on basic fermentation parameters, Food Chemistry, Volume 254, 15 July 2018, Pages 115-121, doi.org/10.1016/j.foodchem.2018.02.005

Palermo A., Forsberg E.M., Warth B., Aisporna A.E., Billings E., Kuang E., Benton H.P., Berry D., Siuzdak G., Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry, ACS Nano, 2018 Jul 24;12(7):6938-6948. doi: 10.1021/acsnano.8b02376.

Huan T., Palermo A., Ivanisevic J., Rinehart D., Edler D., Phommavongsay T., Benton H.P., Guijas C., Domingo-Almenara X., Warth B., Siuzdak G., Autonomous Multimodal Metabolomics Data Integration for Comprehensive Pathway Analysis and Systems Biology, Analytical Chemistry, 2018 Jul 17;90(14):8396-8403. doi: 10.1021/acs.analchem.8b00875.

Miklosi A.G., Del Favero G., Bulat T., Höger H., Shigemoto R., Marko D., Lubec G., Super-resolution Microscopical Localization of Dopamine Receptors 1 and 2 in Rat Hippocampal Synaptosomes, Molecular Neurobiology, 2018 Jun; doi: 10.1007/s12035-017-0688-y.

Dellafiora L., Warth B., Schmidt V., Del Favero G., Mikula H., Fröhlich J., Marko D. An integrated in silico/in vitro approach to assess the xenoestrogenic potential of  Alternaria mycotoxins and metabolites, Food Chemistry, 2018 May 15;248:253-261. doi: 10.1016/j.foodchem.2017.12.013

Guijas C., Montenegro-Burke J.R., Warth B., Spiler M.E., Siuzdak G., Metabolomics activity screening for identifying metabolites that modulate phenotype, Nature Biotechnology, 2018 Apr 5; 36(4):316-320. doi: 10.1038/nbt.4101

Forsberg EM., Huan T., Rinehart D., Benton HP., Warth B., Hilmers B., Siuzdak G., Data processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online, Nature Protocols, 2018 Apr;13(4):633-651. doi: 10.1038/nprot.2017.151.

Varga E., Wiesenberger G., Woelflingseder L., Twaruschek K., Hametner C., Vaclaviková M., Malachová A., Marko D., Berthiller F., Adam G., Less-toxic rearrangement products of NX-toxins are formed during storage and food processing, Toxicology Letters, 2018 Mar 1;284:205-212. doi: 10.1016/j.toxlet.2017.12.016

Jarolim K., Wolters K., Woeflingseder L., Pahlke G., Beisl J., Puntscher H., Braun D., Sulyok M., Warth B., Marko D., The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells, Toxicology Letters, 2018 Mar 1;284:170-183. doi: 10.1016/j.toxlet.2017.12.008

Aichinger G., Puntscher H., Beisl J., Kütt M.L., Warth B., Marko D., Delphinidin protects colon carcinoma cells against the genotoxic effects of the mycotoxin altertoxin II, Toxicology Letters, 2018 Mar 1;284:136-142. doi: 10.1016/j.toxlet.2017.12.002

Warth B., Raffeiner P., Granados A., Huan T., Fang M., Forsberg E.M., Benton H.P., Goeth L., Johnson Ch., Siuzdak G., Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy, Cell Chemical Biology, 2018 March 15, pii: S2451-9456(17)30459-2. doi: 10.1016/j.chembiol.2017.12.010

Guijas C., Montenegro-Burke J.R., Domingo-Almenara X., Palermo A., Warth B., Hermann G., Koellensperger G., Huan T., Uritboonthai W., Aisporna A.E., Wolan D.W., Spilker M.E., Benton H.P., Siuzdak G., METLIN: A Technology Platform for Identifying Knowns and Unknowns, Analytical Chemistry, 2018 March 6 doi: 10.1021/acs.analchem.7b04424

Griesser M., Martinez SC., Eitle MW., Warth B., Andre CM., Schuhmacher R., Forneck A., The ripening disorder berry shrivel affects anthocyanin biosynthesis and sugar metabolism in Zweigelt grape berries, Planta, 2018 Feb;247(2):471-481. doi: 10.1007/s00425-017-2795-4

 

2017

Warth B., Spangler S., Fang M., et al. Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing, Analytical Chemistry, 2017 Nov 7;89(21):11505-11513. doi: 10.1021/acs.analchem.7b02759.

Johnson C.H., Santidrian A.F., LeBoeuf S.E., Kurczy M.E., Rattray N.J.W., Rattray Z., Warth B., Ritland M., Hoang L.T., Loriot C., Higa J., Hansen J.E., Felding B.H., Siuzdak G., Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids, Cancer & Metabolism, 2017 Oct 31;5:9. doi: 10.1186/s40170-017-0171-2. eCollection 2017

Adedeji B.S., Ezeokoli O.T., Ezekiel C.N., Obadina A.O., Somorin Y.M., Sulyok M., Adeleke R.A., Warth B., Nwangburuka C.C., Omemu A.M., Oyewole O.B., Krska R., Bacterial species and mycotoxin contamination associated with locust bean, melon and their fermented products in south-western Nigeria, International Journal of Food Microbiology, 2017 Oct 3;258:73-80. doi: 10.1016/j.ijfoodmicro.2017.07.014. 

Abia W.A., Warth B., Ezekiel C.N., Sarkanj B., Turner P.C., Marko D., Krska R., Sulyok M., Uncommon toxic microbial metabolite patterns in traditionally home-processed maize dish (fufu) consumed in rural Cameroon; Food and Chemical Toxicology, Volume 107, Part A, September 2017, Pages 10-19, doi.org/10.1016/j.fct.2017.06.011

Warth B., Levin N., Rinehart D., et al. Metabolizing Data in the Cloud, Trends in Biotechnology, June 2017, DOI: dx.doi.org/10.1016/j.tibtech.2016.12.010

Jarolim K., Del Favero G., Ellmer D., Stark T.D., Hofmann Th., Sulyok M., Humpf H.U., Marko D., Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase, Archives of Toxicology, April 2017, DOI 10.1007/s00204-016-1855-z

Ogara I.M., Zarafi A.B., Alabi O., Banwo O.,  Ezekiel C.N., Warth B., Sulyok M., Krska R., Mycotoxin patterns in ear rot infected maize: A comprehensive case study in Nigeria, Food Control, Vol. 73, Part B, March 2017, Pages 1159-1168, Doi: 10.1016/j.foodcont.2016.10.034

Tiessen C., Ellmer D., Mikula H., Pahlke G., Warth B., Gehrke H., Zimmermann K., Heiss E., Fröhlich J., Marko D., Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells; Archives of Toxicology, 2017 Mar;91(3):1213-1226. doi: 10.1007/s00204-016-1801-0.

Meier C., Steinhauser TN., Koczian F., Plitzko B., Jarolim K., Girreser U., Braig S., Marko D., Vollmar AM., Clement B., A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment. ChemMedChem, 2017 March 7, doi: 10.1002/cmdc.201700026.

Vejdovszky K., Schmidt V., Warth B, Marko D., Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro. Molecular Nutrition & Food Research, March 2017. doi: 10.1002/mnfr.201600526.

Vejdovszky K., Hahn K., Braun D., Warth B., Marko D., Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro, Archives of Toxicology, March 2017, DOI 10.1007/s00204-016-1795-7

Aichinger G., Beisl J., Marko D., Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells. Molecular Nutrition & Food Research, 2017 Feb;61(2) doi: 10.1002/mnfr.201600462.

Egbontan A.O., Afolabi C.G., Kehinde I.A., Enikuomehin O.A., Ezekiel C.N., Sulyok M., Warth B., Krska R., A mini-survey of moulds and mycotoxins in locally grown and imported wheat grains in Nigeria. Mycotoxin Research, Feb. 2017, 33(1): 59.64. Doi: 10.1007/s12550-016-0264-8

Vejdovszky K., Sack M., Jarolim K., Aichinger G., Somoza M.M., Marko D., In vitro combinatory effects of the Alternaria mycotoxins alternariol and altertoxin II and potentially involved miRNAs. Toxikology Letters, 2017 Feb. 5th, 267: 45-52, doi: 10.1016/j.toxlet.2016.12.011.

Montenegro-Burke J.R., Aisporna A.E., Benton H.P., Rinehart D., Fang M., Huan T., Warth B., Forsberg E., Abe B.T., Ivanisevic J., Wolan D.W., Teyton L., Lairson L., Siuzdak G., Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes, Analytical Chemistry, 2017 Jan 17;89(2):1254-1259. doi: 10.1021/acs.analchem.6b03890. 

Wittig, A., Gehrke, H., Del Favero, G., Fritz, E.-M., Al-Rawi, M., Diabaté, S., Weiss, C., Sami, H., Ogris, M., Marko D., Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells, Nanomaterials, Jan 13 2017, 7, 18; doi:10.3390/nano7010018

Jarolim K., Del Favero G., Pahlke G., Dostal V., Zimmermann K., Heiss E., Ellmer D., Stark TD., Hofmann T., Marko D., Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II, Archives of Toxicology, Jan 2017, DOI 10.1007/s00204-016-1726-7


2016

Groh I., Rudakovski O., Gründken M., Schroeter A., Marko D., Esselen M., Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases, Archives of Toxicology, Nov. 2016, DOI 10.1007/s00204-015-1625-3

Clement B., Girreser U., Steinhauer T.N., Meier Ch., Marko D., Aichinger G., Kaltefleiter I., Stenzel L., Heber D., Weide M., Wolschendorf U., Zebothsen I., Zur Nieden D., 11-Substituted Benzo[c]phenanthridines: New Strucutres and Insight into Their Mode of Antiproliferative Action, CHemMedChem, 2016 Oct, doi: 10.1002/cmdc.201600199

Warth B., Del Favero G., Wiesenberger G., Puntscher H., Woelflingseder L., Fruhmann P., Sarkanj B., Krska R., Schuhmacher R., Adam G., Marko D., Identification of a novel humen deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells, Scientific Reports, 2016 Sep, 23; 6:33854. doi: 10.1038/srep33854

Seriani S., Del Favero G., Mahaffey J., Marko D., Gallina P., Long C. S., Mestroni L., Sbaizero O., The cell-stretcher: A novel device for the mechanical stimulation of cell populations, Review of Scientific Instruments 87, 2016 Aug, 084301 (2016); doi: 10.1063/1.4959884

Aichinger G., Pahlke G., Nagel L. J., Berger W., Marko D., Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells, Food and function, 2016 Aug 10;7(8):3628-3636, DOI: 10.1039/c6fo00570e

Boedi S., Berger H., Sieber Ch., Muensterkoetter M., Maloku I., Warth B., Sulyok M., Lemmens M., Schuhmacher R., Gueldener U., Strauss, J., Comparison of Fusarium graminearum Transcriptomes on Living or Dead Wheat Differentiates Substrate-Responsive and Defense-Responsive Genes, frontiers in Microbiology, July 26th, 2016, doi.org/10.3389/fmicb.2016.01113

Warth B., Braun D., Ezekiel Ch.N., Turner P.C., Degen G.H., Marko D., Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives, Chemical Research in Toxicology, July 18th 2016, doi: 10.1021/acs.chemrestox.6b00125

Vejdovszky K., Warth B., Sulyok M., Marko D., Non-synergistic cytotoxic effects of Fusarium and Alternaria toxin combinations in Caco-2 cells. Toxicology Letters, Jan 22 2016. doi: 10.1016/j.toxlet.2015.10.024

Pahlke G., Tiessen C., Domnanich K., Kahle N., Groh I.A.M., Schreck I., Weiss C., Marko D., Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity, Toxicology Letters, 2016 Jan 5;240(1):93-104. doi: 10.1016/j.toxlet.2015.10.003

 

2015

A. Schroeter, I. A. M. Groh, G. Del Favero, M. Pignitter, K. Schueller, V. Somoza, D. Marko, Inhibition of topoisomerase II by phase II metabolites of RSV in human colon cancer cells. Molecular Nutrition & Food Research, Dec. 2015. doi: 10.1002/mnfr.201500352

Schmeitzl C., Varga E., Warth B., Kugler K.G., Malachova A., Michlmayr H., Wiesenberger G., Mayer K.F.X., Mewes H-W., Krska R., Schuhmacher R., Berthiller F., Adam G., Identifcation and characterization of Carboxylesterases from Brachyppodium distachyon Deacetylating Trichothecene Mycotoxins, Toxins, 2015 Dec 25;8(1). pii: E6. doi: 10.3390/toxins8010006.

Perkin J., Slater R., Del Favero G., Lanzicher Th., Hidalgo C., Anderson B., Smith J.E., Sbaizero O., Labeit S., Granzier H., Phosphorylating Titin´s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force, Biophysical Journal, 2015 Dec 15;109(12):2592-601. doi: 10.1016/j.bpj.2015.11.002

Warth B., Siegwart G., Lemmens M., Krska R., Adam G., Schumacher R., Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for the quanitfication of UDP-glucose, UDP-glucuronic acid, deoxynivalenol and its glucoside: In-house validation and application to wheat, Journal of Chromatography A, Dez. 2015, doi: 10.1016/j.chroma.2015.10.070

Nussbaumer T., Warth B., Sharma S., Ametz C., Bueschl C., Parich A., Pfeifer M., Siegwart G., Steiner B., Lemmens M., Schuhmacher R., Buerstmayr H., Mayer K. FX., Kugler K, Schweiger W., Joint Transcriptomic and Metabolomic Analyses Reveal Changes in the Primary Metabolism and Imbalances in the Subgenome Orchestration in the Bread Wheat Molecular Response to Fusarium Graminearum. G3 Genes / Genomes / Genetics, Oct. 2015, doi: 10.1534/g3.115.021550

Lanzicher T, Martinelli V, Puzzi L, Del Favero G, Codan B, Long CS, Mestroni L, Taylor MR, Sbaizero: The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Scientific Reports, Sept. 2015. doi: 10.1038/srep13388.

Schmeitzl C., Warth B., Fruhmann Ph., Michlmayr H., Malachova A., Berthiller F., Schumacher R., Krska R., Adam G., The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-0-Glucoside, 15-Acetyl-DON-3-0-Glucoside and 15-Acetyl-DON-3-Sulfate. Toxins, Aug. 2015, doi: 10.3390/toxins7083112

Lanzicher T. , Martinelli V. , Long C. S. , Del Favero G. , Puzzi L. , Borelli M. , Mestroni L. , Taylor M. R.G., Sbaizero O., AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus, Aug. 2015. DOI:10.1080/19491034.2015.1084453

Rohm B., Holik A-K., Kretschy N., Somoza M.M., Ley J.P., Widder S., Krammer G.E., Marko D., Somoza V., Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PRARy expression in 3T3-L1 cells. Journal of Cellular Biochemistry, June 2015, DOI: 10.1002/jcb.25052

Warth B., Parich A., Bueschl C., et al. GC-MS based targeted metabolic profiling identifies changes in the wheat metabolome following deoxynivalenol treatment, Metabolomics, June 2015, Volume 11, Issue 3, pp 722–738, DOI: 10.1007/s11306-014-0731-1

Sbaizero O. , Del Favero G. , Martinelli V. , Long C.S. , Mestroni L., Analysis of long- and short-range contribution to adhesion work in cardiac fibroblasts: An atomic force microscopy study. Materials Science and Engineering C, 49 217–224, Apr. 2015. doi: 10.1016/j.msec.2014.12.083

Habermeyer M., Roth A., Guth S., Diel P., Engel K.H., Epe B., Furst P., Heinz V., Humpf H.U., Joost H.G., Knorr D., de Kok T., Kulling S., Lampen A., Marko D., Rechkemmer G., Rietjens I., Stadler R.H., Vieths S., Vogel R., Steinberg P., and Eisenbrand G., Nitrate and nitrite in the diet: How to assess their benefit and risk for human health. Molecular Nutrition & Food Research, Jan. 2015, 59, 106-128, DOI: 10.1002/mnfr.201400286

 

2014

Schroeter A., Marko D., Resveratrol Modulates the Topoisomerase Inhibitory Potential of Doxorubicin in Human Colon Carcinoma Cells, Molecules, Dec. 2014, 19, 20054-20072; doi:10.3390/molecules191220054

Rychlik M., Humpf H-U., Marko D., Dänicke S., Mally A., Berthiller F., Klaffke H., Lorenz N., Proposal of a comprehensive definition of modified and other forms of mycotoxins including "masked" mycotoxins. Mycotoxin Research, Volume 4, November 2014, Pages 197-205; DOI: 10.1007/s12550-014-0203-5

Winkler S., Dieminger N., Blust V., Riedel A., Bakuradze T., Montoya G., Hassmann U., Lang R., Hofmann T., Somoza V., Richling E., Bytof G., Stiebitz H., Lantz I., Schipp D., Raedle J., Marko D., Modulation of inflammatory gene transcription after long-term coffee consumption. Food Research International, Volume 63 / Part C, September 2014, Pages 428–438, DOI: 10.1016/j.foodres.2014.05.073

Riedel A., Dieminger N., Bakuradze T., Lang R., Montoya G., Hochkogler C.M., Winkler S., Bytof G., Lantz I., Stiebitz H., Richling E., Hofmann T., Marko D., Schipp D., Raedle J., Somoza V., A 4-week consumption of medium roast and dark roast coffee affects parameters of energy status in healthy subjects. Food Research International, 63:409-419 · September 2014, DOI: 10.1016/j.foodres.2014.04.002

Bakuradze T., Montoya Parra G., Riedel A., Somoza V., Lang R., Dieminger N., Hofmann T., Winkler S., Hassmann U., Marko D., Schipp D., Raedle J., Bytof G., Lantz I., Stiebitz H., Richling E., Four weeks coffee consumption affects energy intake, satiety regulation, body fat, and protects DNA integrity. Food Research International, Volume 63, Part C, September 2014, Pages 420–427DOI: 10.1016/j.foodres.2014.05.032

Hassmann U., Haupt L.M., Smith R.A., Winkler S., Bytof G., Lantz I., Griffiths L.R., Marko D., Potential antioxidant response to coffee – A matter of genotype? Meta Gene, Volume 2, August 2014, Pages 525-539, DOI: 10.1016/j.mgene.2014.07.003

Baechler S.A., Schroeter A., Walker J., Aichinger G., Marko D., Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein. Molecular Nutrition & Food Research, 2014 Jun,58(6):1269-81. DOI: 10.1002/mnfr.201300531.

Blank H., Schneider R., Gerthsen D., Gehrke H., Jarolim K., Marko D., Application of low-energy scanning transmission electron microscopy for the study of Pt-nanoparticle uptake in human colon carcinoma cells. Nanotoxicology, 2014 Jun,8(4):433-46.

Seiter J, Müller E, Blank H, Gehrke H, Marko D, Gerthsen D. Backscattered electron SEM imaging of cells and determination of the information depth. Journal of Microscopy, 2014 May,254(2):75-83. DOI: 10.1111/jmi.12120.

Del Favero G., Sosa S., Poli M., Tubaro A., Sbaizero O., Lorenzon P: In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: structural and functional impairment, Toxicology Letters, 225: 285-293, March 2014;  doi: 10.1016/j.toxlet.2013.12.020

Baechler S.A., Schroeter A., Dicker M., Steinberg P., Marko D., Topoisomerase II-Targeting Properties of a Grapevine-Shoot Extract and Resveratrol Oligomers. Journal of Agricultural and Food Chemistry, 2014 Jan 10. DOI: 10.1021/jf4046182

 

2013

Thiele W., Rothley M., Teller N., Jung N., Bulat B., Plaumann D., Vanderheiden S., Schmaus A., Cremers N., Göppert B., Dimmler A., Eschbach V., Quagliata L., Thaler S., Marko D., Bräse S., Sleeman J.P., Delphinidin is a novel inhibitor of lymphangiogenesis, but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis. 2013 Dec,34(12):2804-13.

Tiessen C., Gehrke H., Kropat C., Schwarz C., Bächler S., Fehr M., Pahlke G., Marko D., Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II. World Mycotoxin Journal, August 2013, 6 (3): 233-244.

Kropat C., Betz M., Kulozik U., Leick S., Rehage H., Boettler U., Teller N., Marko D., Effect of microformulation on the bioactivity of an anthocyanin-rich bilberry pomace extract ( Vaccinium myrtillus L.) in vitro. Journal of Agricultural and Food Chemistry, 2013 May 22,61(20):4873-81.

Gehrke H., Frühmesser A., Pelka J., Esselen M., Hecht L.L., Blank H., Schuchmann H.P., Gerthsen D., Marquardt C., Diabaté S., Weiss C., Marko D., In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. Nanotoxicology, 2013 May,7(3):274-93.

Teller N., Roth M., Esselen M., Fridrich D., Boettler U., Blust V., Will F., Dietrich H., Raul F., Hümmer W., Richling E., Schreier P., Marko D., Apple procyanidins affect several members of the ErbB receptor tyrosine kinase family in vitro. Food & Function, 2013 Apr 30,4(5):689-97.

Esselen M., Barth S.W., Winkler S., Baechler S., Briviba K., Watzl B., Skrbek S., Marko D,. Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. Carcinogenesis, 2013 Apr,34(4):835-40.

Kropat C., Mueller D., Boettler U., Zimmermann K., Heiss E.H., Dirsch V.M., Rogoll D., Melcher R., Richling E., Marko D., Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo. Molecular Nutrition & Food Research, 2013 Mar,57(3):545-50.

Baechler S.A., Fehr M., Habermeyer M., Hofmann A., Merz K.H., Fiebig H.H., Marko D., Eisenbrand G., Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. Bioorganic & Medicinal Chemistry, 2013 Feb 1,21(3):814-23.

Pelka J., Gehrke H., Rechel A., Kappes M., Hennrich F., Hartinger C.G., Marko D., DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells. Nanotoxicology, 2013 Feb,7(1):2-20.

Tiessen C., Fehr M., Schwarz C., Baechler S., Domnanich K., Böttler U., Pahlke G., Marko D., Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether. Toxicolicology Letters, 2013 Jan 10,216(1):23-30.

 

2012

Kurzwernhart A., Kandioller W., Bächler S., Bartel C., Martic S., Buczkowska M., Mühlgassner G., Jakupec M.A., Kraatz H.B., Bednarski P.J., Arion V.B., Marko D., Keppler B.K., Hartinger CG., Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands. J Med Chem. 2012 Dec 13,55(23):10512-22.

Schwarz C., Tiessen C., Kreutzer M., Stark T., Hofmann T., Marko D., Characterization of a genotoxic impact compound in Alternaria alternata infested rice as Altertoxin II. Archives of Toxicology 2012 Dec,86(12):1911-25.

Volz N., Boettler U., Winkler S., Teller N., Schwarz C., Bakuradze T., Eisenbrand G., Haupt L., Griffiths L.R., Stiebitz H., Bytof G., Lantz I., Lang R., Hofmann T., Somoza V., Marko D., Effect of Coffee Combining Green Coffee Bean Constituents with Typical Roasting Products on the Nrf2/ARE Pathway in Vitro and in Vivo. Journal of Agricultural and Food Chemistry, 2012 Sep 26,60(38):9631-41.

Schwarz C., Kreutzer M., Marko D., Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicology Letters (2012) 214:46–52.

Boettler U., Volz N., Teller N., Haupt L.M., Bakuradze T., Eisenbrand G., Bytof G., Lantz I., Griffiths L.R., Marko D., Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype? Mol Biol Rep. 2012 Jun,39(6):7155-62.

Kurzwernhart A., Kandioller W., Bartel C., Bächler S., Trondl R., Mühlgassner G., Jakupec M.A., Arion V.B., Marko D., Keppler B.K., Hartinger C.G., Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder. Chem Commun (Camb). 2012 May 18,48(40):4839-41.

Schreck I., Deigendesch U., Burkhardt B., Marko D., Weiss C., The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor. Archives of Toxicology 2012 Apr,86(4):625-32.

 

2011

Kotyczka C., Boettler U., Lang R., Stiebitz H., Bytof G., Lantz I., Hofmann T., Marko D., Somoza V., Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers. Molecular Nutrition & Food Research 2011, 55, (10), 1582-6.

Esselen M., Boettler U., Teller N., Bächler S., Hutter M., Rüfer C.E., Skrbek S., Marko D., Anthocyanin-Rich Blackberry Extract Suppresses the DNA-Damaging Properties of Topoisomerase I and II Poisons in Colon Carcinoma Cells. Journal of Agricultural and Food Chemistry, 2011 Jul 13,59(13):6966-6973.

Gehrke H., Pelka J., Hartinger C.G., Blank H., Bleimund F., Schneider R., Gerthsen D., Bräse S., Crone M., Türk M., Marko D., Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations. Archives of Toxicology, 2011 Jul,85(7):799-812.

Kalfalah F.M., Mielke C., Christensen M.O., Baechler S., Marko D., Boege F., Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S127-42.

Boettler U., Volz N., Pahlke G., Teller N., Kotyczka C., Somoza V., Stiebitz H., Bytof G., Lantz I., Lang R., Hofmann T., Marko D., Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S143-53.

Esselen M., Fritz J., Hutter M., Teller N., Baechler S., Boettler U., Marczylo T.H., Gescher A.J., Marko D., Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S143-53.

Boettler U., Sommerfeld K., Volz N., Pahlke G., Teller N., Somoza V., Lang R., Hofmann T., Marko D., Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J Nutr. Biochem. 2011 May,22(5):426-40

 

2010

Cai H., Marczylo T.H., Teller N., Brown K., Steward W.P., Marko D., Gescher AJ., Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase. Eur J Cancer 2010, 46, (4), 811-7.

Barth S.W., Briviba K., Watzl B., Jager N., Marko D., Esselen M., In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats. Biotechnol. J. 2010, 5, (3), 321-7.

Fehr M., Baechler S., Kropat C., Mielke C., Boege F., Pahlke G., Marko D., Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1. Mycotoxin Research 2010, 26, (4), 247-256.

 

2009

Thomasset S., Teller N., Cai H., Marko D., Berry D.P., Steward W.P., Gescher A.J., Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? Cancer Chemother Pharmacol 2009, 64, (1), 201-11.

Teller N., Thiele W., Marczylo T.H., Gescher A.J., Boettler U., Sleeman J., Marko D., Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. Journal of Agricultural and Food Chemistry, 2009, 57, (8), 3094-101.

Teller N., Thiele W., Boettler U., Sleeman J., Marko D., Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Molecular Nutrition & Food Research 2009, 53, (9), 1075-83.

Pelka J., Gehrke H., Esselen M., Turk M., Crone M., Brase S., Muller T., Blank H., Send W., Zibat V., Brenner P., Schneider R., Gerthsen D., Marko D., Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity. Chem. Res. Toxicol. 2009, 22, (4), 649-59.

Fehr M., Pahlke G., Fritz J., Christensen M.O., Boege F., Altemoller M., Podlech J., Marko D., Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Molecular Nutrition & Food Research2009, 53, (4), 441-51.

Esselen M., Fritz J., Hutter M., Marko D., Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons. Chem. Res. Toxicol. 2009.

Skrbek S., Rufer C.E., Marko D., Esselen M., Quercetin and its microbial degradation product 3,4-dihydroxyphenylacetic acid generate hydrogen peroxide modulating their stability under in vitro conditions. J. Food Nutr. Res. 2009, 48, (3), 129-140.

Dornetshuber R., Heffeter P., Lemmens-Gruber R., Elbling L., Marko D., Micksche M., Berger W., Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction. Molecular Nutrition & Food Research 53 (9):1112-22, 2009. 10.1002/mnfr.200800571

 

2008

Fritz J., Roth M., Holbach P., Esselen M., Marko D., Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells. Journal of Agricultural and Food Chemistry, 2008, 56, (19), 8891-6.

Fridrich D., Teller N., Esselen M., Pahlke G., Marko D., Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Molecular Nutrition & Food Research 2008, 52, (7), 815-22.

Fridrich D., Glabasnia A., Fritz J., Esselen M., Pahlke G., Hofmann T., Marko D., Oak ellagitannins suppress the phosphorylation of the epidermal growth factor receptor in human colon carcinoma cells. Journal of Agricultural and Food Chemistry, 2008, 56, (9), 3010-5.

 

2007

Kern M., Pahlke G., Balavenkatraman K.K., Bohmer F.D., Marko D., Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. Journal of Agricultural and Food Chemistry, 2007, 55, (13), 4999-5006.

Kern M., Fridrich D., Reichert J., Skrbek S., Nussher A., Hofem S., Vatter S., Pahlke G., Rufer C., Marko D., Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. Molecular Nutrition & Food Research 2007, 51, (9), 1163-72.

Fridrich D., Kern M., Pahlke G., Volz N., Will F., Dietrich H., Marko D., Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells. Molecular Nutrition & Food Research 2007, 51, (5), 594-601.

Fridrich D., Kern M., Fritz J., Pahlke G., Kohler N., Winterhalter P., Marko D., The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins. Molecular Nutrition & Food Research 2007, 51, (2), 192-200.

 

2006

Pahlke G., Ngiewih Y., Kern M., Jakobs S., Marko D., Eisenbrand G., Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. Journal of Agricultural and Food Chemistry, 2006, 54, (19), 7075-82.

Kern M., Pahlke G., Ngiewih Y., Marko D., Modulation of key elements of the Wnt pathway by apple polyphenols. Journal of Agricultural and Food Chemistry, 2006, 54, (19), 7041-6.

Fritz J., Kern M., Pahlke G., Vatter S., Marko D., Biological activities of malvidin, a red wine anthocyanidin. Molecular Nutrition & Food Research 2006, 50, (4-5), 390-5.

Jakobs S., Fridrich D., Hofem S., Pahlke G., Eisenbrand G., Natural flavonoids are potent inhibitors of glycogen phosphorylase, Molecular Nutrition & Food Research, 2006 Jan;50(1):52-7, DOI:10.1002/mnfr.200500163

 

2005

Puppel N., Tjaden Z., Fueller F., Marko D., DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells. Mutat. Res. 2005, 580, (1-2), 71-80.

Kern M., Tjaden Z., Ngiewih Y., Puppel N., Will F., Dietrich H., Pahlke G., Marko D., Inhibitors of the epidermal growth factor receptor in apple juice extract. Molecular Nutrition & Food Research 2005, 49, (4), 317-28.

S. Vatter, G. Pahlke, J.W. Deitmer, and G. Eisenbrand. Differential phosphodiesterase expression and cytosolic Ca2+ in CNS tumour cells of human and rat origin. J Neurochem. 2005 Apr;93(2):321-9. DOI:10.1111/j.1471-4159.2005.03028.x

Habermeyer M., Fritz J., Barthelmes H. U., Christensen M. O., Larsen M. K., Boege F., Marko D., Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. Chem. Res. Toxicol. 2005, 18, (9), 1395-404.

 

2004 - 1998

Marko D., Puppel N., Tjaden Z., Jakobs S., Pahlke G., The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Molecular Nutrition & Food Research2004, 48, (4), 318-25.

Grant K. M., Dunion M. H., Yardley V., Skaltsounis A. L., Marko D., Eisenbrand G., Croft S. L., Meijer L., Mottram J. C., Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrob. Agents Chemother. 2004, 48, (8), 3033-42.

Barthelmes H. U., Habermeyer M., Christensen M. O., Mielke C., Interthal H., Pouliot J. J., Boege F., Marko D., TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II. J. Biol. Chem. 2004, 279, (53), 55618-25.

Marko D., Habermeyer M., Kemeny M., Weyand U., Niederberger E., Frank O., Hofmann T., Maillard reaction products modulating the growth of human tumor cells in vitro. Chem. Res. Toxicol. 2003, 16, (1), 48-55.

Wagner B., Jakobs S., Habermeyer M., Hippe F., Cho-Chung Y. S., Eisenbrand G., Marko D., 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells. Biochem. Pharmacol. 2002, 63, (4), 659-68.

Marko D., Merz K. H., Kunz C., Muller A., Tarasova N., Eisenbrand G., Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase. Biochem. Pharmacol. 2002, 63, (4), 669-76.

Marko D., Kemeny M., Bernady E., Habermeyer M., Weyand U., Meiers S., Frank O., Hofmann T., Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensively coloured Maillard reaction product. Food Chem. Toxicol. 2002, 40, (1), 9-18.

I. Verde, G. Pahlke, M. Salanova, G. Zhang, S. Wang, D. Coletti, J. Onuffer, S.-L. C. Jin, and M. Conti. Myomegalin: a novel protein of Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. J Biol Chem., 2001 Apr 6;276(14):11189-98. DOI:10.1074/jbc.M006546200

Meiers S., Kemeny M., Weyand U., Gastpar R., von Angerer E., Marko D., The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. Journal of Agricultural and Food Chemistry, 2001, 49, (2), 958-62.

Marko D., Schatzle S., Friedel A., Genzlinger A., Zankl H., Meijer L., Eisenbrand G., Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. Br. J. Cancer 2001, 84, (2), 283-9.

Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J. A., Snyder G. L., Greengard P., Biernat J., Wu Y. Z., Mandelkow E. M., Eisenbrand G., Meijer L., Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J. Biol. Chem. 2001, 276, (1), 251-60.

Davies T. G., Tunnah P., Meijer L., Marko D., Eisenbrand G., Endicott J. A., Noble M. E., Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure 2001, 9, (5), 389-97.

Barthelmes H. U., Niederberger E., Roth T., Schulte K., Tang W. C., Boege F., Fiebig H. H., Eisenbrand G., Marko D., Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. Br. J. Cancer 2001, 85, (10), 1585-91.

Amara M. O., Franetich J. F., Bouladoux N., Mazier D., Eisenbrand G., Marko D., Meijer L., Doerig C., Desportes-Livage I., In vitro activity of antimitotic compounds against the microsporidium Encephalitozoon intestinalis. J Eukaryot Microbiol 2001, Suppl, 99S-100S.

Marko D., Pahlke G., Merz K. H., Eisenbrand G., Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy. Chem. Res. Toxicol. 2000, 13, (10), 944-8.

Lim J., Pahlke G., and Conti M., Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain. J Biol Chem., 1999 Jul 9;274(28):19677-85.

Hoessel R., Leclerc S., Endicott J. A., Nobel M. E., Lawrie A., Tunnah P., Leost M., Damiens E., Marie D., Marko D., Niederberger E., Tang W., Eisenbrand G., Meijer L., Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat. Cell Biol. 1999, 1, (1), 60-7.

Merz K. H., Marko D., Regiert T., Reiss G., Frank W., Eisenbrand G., Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth. J. Med. Chem. 1998, 41, (24), 4733-43.

Marko D., Romanakis K., Zankl H., Furstenberger G., Steinbauer B., Eisenbrand G., Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts. Cell Biochem. Biophys. 1998, 28, (2-3), 75-101.

Gastpar R., Goldbrunner M., Marko D., von Angerer E., Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. J. Med. Chem. 1998, 41, (25), 4965-72.

Schneider HH., Pahlke G., and Schmiechen R., Sensitivity of a cAMP PDE to rolipram in different organs, Signal Transduction and Protein phosphorylation, edited by L.M.C. Heilmeyer, 1987, DOI doi.org/10.1007/978-1-4757-0166-1_10