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"Shock adsorbing capacity of the Endoplasmic Reticulum"

Endoplasmic Reticulum (ER) plays a central role in regulating protein turnover and homeostasis. At the same time it serves as intracellular reservoir for Ca2+ and contributes to maintain intracellular ionic equilibrium. Upon need, ER can modify its shape within minutes and support cell response to external stressors, as for instance with the activation of the Unfolded Protein Response (UPR) pathway. In order to allow this fast response, timely structural remodeling must occur within the cell.


Dr. Giorgia Del Favero: / 01-4277-70803

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Heidelinde Schweighofer:
Johannes Ernst Seybert:


as soon as possible