Open Positions

Master Thesis

"The combinatory effect of mycotoxin alternariol (AOH) and high glucose on the viability and invasiveness of colorectal cancer cells"

The thesis in dedicated to evaluate the effect of high glucose on mycotoxin-induced changes in cells’ viability and invasiveness of colorectal cancer cells.

Hyperglycaemia is one of the risk factors of colorectal cancer (CRC), whereas estrogens are believed to play a protective role in it. Mycotoxins present in everyday diet affect the hormonal homeostasis both in animals, as well as humans. Alternariol (AOH) is an emerging mycotoxin, considered as estrogenic and immunomodulatory. In this project we would like to evaluate if and how AOH effect might be exacerbated or restrained by high glucose in intestinal cells. Thus, the aim of this study is to evaluate the combinatory effect of high glucose intake and AOH on human colon cancer cells. The results of the study will help to estimate how two different environmental factors might affect the intestinal cells linking the ingested mycotoxins and the high glucose intake associated with obesity.

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Master Thesis

"Optimization of sample preparation workflows forhigh-throughput exposomics"

This thesis in the field of bioanalytical chemistry is dedicated to the development andoptimization of a workflow for high throughput LC-MS-based sample preparation inexposomic and metabolomic research.

Exposure to environmental chemicals plays a critical role in the onset of diseases. Exposomeresearch aims to monitor relevant exogenous chemicals in human samples using a holisticapproach that can associate exposure levels with health outcomes. Due to its high sensitivityand selectivity, LC-MS is the key technology used to characterize these associations. To enablethe high-throughput capacity required, optimized high-throughput sample preparationworkflows are a key element that will be tested within this thesis.

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