Publications of Prof. Marko

2025

Judith Gufler, Petra Heffeter, Christian R. Kowol, Sonja Hager, Doris Marko, Opposing effects of mycotoxins alternariol and deoxynivalenol on the immunomodulatory effects of oxaliplatin and triapine, Toxicology, February 2025, DOI: 10.1016/j.tox.2024.154039

2024

Prause H-Ch. , Berk D. , Alves-de-Souza C. , Hansen P.J. , Larsen Th.O. , Marko D. , Del Favero G. , Place A. , Varga E., How relevant are sterols in the mode of action of prymnesins?, Aquatic Toxikology, November 2024, DOI: 10.1016/j.aquatox.2024.107080

Labuda R., Bacher M., Rosenau Th., Gratzl H., Doppler M., Hager S., Marko D., Wiesner Ch., Očková M., Ollinger N., Wagner M., Schüller Ch., Strauss J., Chemical composition of anti-microbially active fractions derived from extract of filamentous fungus Keratinophyton Lemmensii including three novel bioactive compounds, scientific reports, 2024 Oct 25, DOI: 10.1038/s41598-024-75510-1

Crudo F., Partsch V., Braga D., Blažević R., Rollinger J.M., Varga E., Marko D., Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro, Archives of Toxicology, Oct. 2, 2024, DOI: 10.1007/s00204-024-03877-1

Del Favero G., Bergen J., Palm L., Fellinger Ch., Matlaeva M., Szabadi A., Fernandes A.S., Saraiva N., Schröder Ch., Marko D., Short-Term Exposure to Foodborne Xenoestrogens Affects Breast Cancer Cell Morphology and Motility Relevant for Metastatic Behavior In Vitro, Chemical Research in Toxicology, September 11, 2024, DOI: 10.1021/acs.chemrestox.4c00061

Beisl J., Jochum K., Chen Y., Varga E., Marko D., Combinatory Effects of Acrylamide and Deoxynivalenol on In Vitro Cell Viability and Cytochrome P450 Enzymes of Human HepaRG Cells, Toxins, September 10, 2024, DOI: 10.3390/toxins16090389

Crudo F., Partsch V., Petri P., Braga D., Danklmaier A.C., Rollinger J.M., Varga E., Berry D., Marko D., P25-24 Unlocking nature's arsenal: discovery of Alternaria mycotoxins as novel immunosuppressive and gut microbiota-targeting compounds, Toxicology Letters, September 2024, DOI: 10.1016/j.toxlet.2024.07.860

Jobst M., Crudo F., Di Franco J., Marko D., Cerbino R., Gerner C., Del Favero G., P13-32 Bafilomycin induces mitochondrial reorganization, nuclear deformation and γH2AX increase in T24 bladder cancer cells, Toxicology Letters, September 2024, DOI: 10.1016/j.toxlet.2024.07.548

Hellwig M., Diel P., Eisenbrand G., Grune T., Guth S., Henle Th., Humpf H-U., Joost H-G., Marko D., Raupbach J., Roth A., Vieths S., Mally A., Dietary glycation compounds - implications for human health, Critical Reviews in Toxicology, 2024 Sep, DOI: 10.1080/10408444.2024.2362985

Iriarte-Mesa C., Bergen J., Danielyan K., Crudo F., Marko D., Kählig H., Del Favero G., Kleitz F., Functionalization of Silica Nanoparticles for Tailored Interactions with Intestinal Cells and Chemical Modulation of Paracellular Permeability, Small Science, 01 August 2024, DOI: 10.1002/smsc.202400112

Varga E., Marko D., Meyer K. , Cramer B. , Humpf H-U., Plötz M., Vienna, the "City of Music", meets mycotoxin research at the 45th Mycotoxin Workshop, Mycotoxin Research, 2024 Aug, DOI: 10.1007/s12550-024-00542-5

Borsos E., Varga E., Georg Aichinger G., Marko D., Unraveling Interspecies Differences in the Phase I Hepatic Metabolism of Alternariol and Alternariol Monomethyl Ether: Closing Data Gaps for a Comprehensive Risk Assessment, Chemical Research in Toxicology, 2024 Jul 19, DOI: 10.1021/acs.chemrestox.4c00095, Online ahead of Print

Schmutz C., Plaza C., Steiger F., Stoirer N., Gufler J., Pahlke G., Will F., Walter Berger W., Marko D., Anthocyanin-Rich Berry Extracts Affect SN-38-Induced Response: A Comparison of Non-Tumorigenic HCEC-1CT and HCT116 Colon Carcinoma Cells, antioxidants, July 15, 2024 , DOI: 10.3390/antiox13070846

Peach J.T., Puntscher H., Höger H., Marko D., Warth B., Rats exposed to Alternaria toxins in vivo exhibit altered liver activity highlighted by disruptions in riboflavin and acylcarnitine metabolism, Archives of Toxicology, 2024 Jun 28, DOI: 10.1007/s00204-024-03810-6

Ingels A., Scott R., Hooper A.R., Van der Westhuyzen A.E., Wagh S.B., De Meester J., Maddau L., Marko D., Aichinger G., Berger W., Vermeersch M., Pérez-Morga D., Maslivetc V.A., Evidente A., Van Otterlo W.A.L., Kornienko A., Mathieu V., New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells, scientific reports, 2024 Jun 25, DOI: 10.1038/s41598-024-65335-3

Leist M., Buettner A., Diel P., Eisenbrand G., Epe B., Först P., Grune T., Haller D., Heinz V. , Hellwig M., Humpf H-U., Jäger H., Kulling S.E., Mally A., Marko D., Nöthlings U., Röhrdanz E., Spranger J., Vieths S., Wätjen W. , Hengstler J.G., Controversy on health-based guidance values for bisphenol A-the need of criteria for studies that serve as a basis for risk assessment, Archives of Toxicology, 2024 May 28., DOI: 10.1007/s00204-024-03778-3

Eisenbrand G., Buettner A., Die P., Epe B., Först P., Grune T., Haller D., Heinz V., Hellwig M., Humpf H-U., Jäger H., Kulling S., Lampen A., Leist M., Mally A., Marko D., Nöthlings U., Röhrdanz E., Spranger J., Steinberg P., Vieths S., Wätjen W., Hengstler J.G., Commentary of the SKLM to the EFSA opinion on risk assessment of N‑nitrosamines in food, Archives of Toxicology, April 2024, DOI: 10.1007/s00204-024-03726-1

Zazirna M., Tischler S., Marko D., Varga E., Castejon N., Ultrasound-based strategies for the recovery of microalgal carotenoids: Insights from green extraction methods to UV/MS-based identification, Food Research International, April 2024, DOI: 10.1016/j.foodres.2024.114354

Crudo F., Dellafiora L., Hong Ch., Burger L., Jobst M., Del Favero G., Marko D., Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways, Toxicology Letters, 2024 April, DOI: 10.1016/j.toxlet.2024.02.008

Varga E., Prause H-Ch., Riepl M., Hochmayr N., Berk D., Attakpah E., Kiss E., Medić N., Del Favero G., Ostenfeld Larsen Th., Hansen P.J., Marko D., Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT, Archives of Toxicology, 2024 Jan 11, DOI: 10.1007/s00204-023-03663-5

Jobst M., Hossain M., Kiss E., Bergen J., Marko D., Del Favero G., Autophagy modulation changes mechano-chemical sensitivity of T24 bladder cancer cells, Biomedicine & Pharmacotherapy, Volume 170, January 2024, DOI: 10.1016/j.biopha.2023.115942

2023

Louro H., Vettorazzi A., López de Cerain A., Spyropoulou A., Solhaug A., Straumfors A., Behr A-C., Mertens B., Žegura B., Kruse Fæste C., Ndiaye D., Spilioti E., Varga E., Dubreil E., Borsos E., Crudo F., Sundstøl Eriksen G., Snapkow I., Henri J. 11 , Sanders J. 6 , Machera K. 3 , Gaté L., Le Hegarat L., Novak M., Smith N.M., Krapf S., Hager S., Fessard V., Kohl Y., Silva M.J., Dirven H., Dietrich J., Marko D., Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health, Archives of Toxicology, 2023 Dec 26, DOI: 10.1007/s00204-023-03636-8

Crudo F., Hong Ch., Varga E., Del Favero G., Marko D., Genotoxic and Mutagenic Effects of the Alternaria Mycotoxin Alternariol in Combination with the Process Contaminant Acrylamide, Toxins, Nov. 24, 2023, DOI: 10.3390/toxins15120670

Schmutz C., Will F., Varga E., Jaunecker C., Pahlke G., Berger W., Marko D., In Vitro Inhibitory Potential of Different Anthocyanin-Rich Berry Extracts in Murine CT26 Colon Cancer Cells, Molecules, Nov 21, 2023, DOI: 10.3390/molecules28237684

Grgic D., Novak B., Varga E., Marko D., Estrogen receptor α interaction of zearalenone and its phase I metabolite α-zearalenol in combination with soy isoflavones in hERα-HeLa-9903 cells, Mycotoxin Research, 2023 Oct 17, DOI: 10.1007/s12550-023-00506-1

Cartus A.T., Lachenmeier D.W., Guth S., Roth A., Baum M., Diel P., Eisenbrand G., Engeli B., Hellwig M., Humpf H-U., Joost H-G., Kulling S.E., Lampen A., Marko D., Steinberg P., Wätjen W., Hengstler J.G., Mally A., Acetaldehyde as a Food Flavoring Substance: Aspects of Risk Assessment, Molecular Nutrition and Food Research, 2023 Oct 15, DOI: 10.1002/mnfr.202200661

Bloch D., Diel P., Epe B., Hellwig M., Lampen A., Mally A., Marko D., Villar Fernández M. A., Guth S., Roth A., Marchan R., Ghallab A., Cadenas C., Nell P., Vartak N., Van Thriel Ch., Luch A., Schmeisser S., Herzler M., Landsiedel R., Leist M., Marx-Stoelting Ph., Tralau T., Hengstler J.G., Basic concepts of mixture toxicity and relevance for risk evaluation and regulation, Archives of Toxicology, 2023, Aug 24, DOI: 10.1007/s00204-023-03565-6

Iriarte-Mesa C., Jobst M. Bergen J., Kiss E., Ryoo R., Kim J.-C., Crudo F., Marko D., Kleitz F., Del Favero G., Morphology-Dependent Interaction of Silica Nanoparticles with Intestinal Cells: Connecting Shape to Barrier Function, Nano Letters, July 11, 2023, DOI: 10.1021/acs.nanolett.3c00835

Bergen J., Karasova M., Bileck A., Pignitter M., Marko D., Gerner Ch., Del Favero G., Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro, Archives of Toxicology, June, 2023, DOI:10.1007/s00204-023-03495-3

Pavicich M. A., De Boevre M., Vidal A., Mikula H., Warth B., Marko D., De Saeger S., Patriarca A., Natural occurrence, exposure assessment & risk characterization of Alternaria mycotoxins in apple by‑products in Argentina, Exposure and Health, April 3, 2023, DOI: 10.1007/s12403-023-00544-1

Guth S., Baum M., Cartus A.T., Diel P., Engel K-H., Engeli B., Epe B., Grune T., Haller D., Heinz V., Hellwig M., Hengstler J.G., Henle Th., Humpf H-U., Jäger H., Joost H-G., Kulling S.E., Lachenmeier D.W., Lampen A., Leist M., Mally A., Marko D., Nöthlings U., Röhrdanz E., Roth A., Spranger J., Stadler R., Steinberg P., Vieths S., Wätjen W., Eisenbrand G., Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value), Food and Chemical Toxicology, March, 2023, DOI: 10.1016/j.fct.2023.113632

Lu J., Yang Y., Varga E., Marko D., Yu Q., Xie J., Li Ch., Chen Y., Molecular Mechanisms Associated with Protecting IEC-6 Cells from Acrylamide-Induced Tight Junction Damage by Ganoderma Atrum Polysaccharide, Molecular Nutrition and Food Research, March, 2023, DOI: 10.1002/mnfr.202200774

Jobst M., Kiss E., Gerner Ch., Marko D., Del Favero G., Activation of autophagy triggers mitochondrial loss and changes acetylation profile relevant for mechanotransduction in bladder cancer cells, Archives of Toxicology, January 2023, DOI: 10.1007/s00204-022-03375-2

2022

Grgic D., Betschler A., Früholz R., Novak B., Varga E., Marko D., Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones, Archives of Toxicology, Dec. 2022, DOI: 10.1007/s00204-022-03358-3

Aichinger G., Pahlke G., Puntscher H., Groestlinger J., Grabher S., Braun D., Tillmann K., Plasenzotti R., Del Favero G., Warth B., Höger H., Marko D., Markers for DNA damage are induced in the rat colon by the Alternaria toxin altertoxin-II, but not a complex extract of cultured Alternaria alternata, Frontiers in Toxicology, Oct. 24, 2022, DOI: 10.3389/ftox.2022.977147

Hohagen M., Guggenberger P., Kiss E., Kählig H., Marko D., Del Favero G., Kleitz F., TANNylation of Mesoporous Silica Nanoparticles and Bioactivity Profiling in Intestinal Cells, Journal of Colloid and Interface Science, October 2022, DOI: 10.1016/j.jcis.2022.05.035

Del Favero G., Jobst M., Kiss E., Marko D., P12-25 Response profile of bladder cells to environmental stressors: how modulation of autophagy reflects on biomechanical compliance, Toxicology Letters, Volume 368, Supplement, Sept. 1, 2022, Page S184, DOI: org/10.1016/j.toxlet.2022.07.504

Hengstler J.G., Baum M., Cartus A.T., Diel P., Eisenbrand G., Engel K-H., Engeli B., Epe B., Grune T., Guth S., Haller D., Heinz V., Hellwig M., Henle Th., Humpf H-U., Jäger H., Joost H-G., Kulling S.E., Lachenmeier D.W., Lampen A., Leist M., Mally A., Marko D., Nöthlings U., Röhrdanz E., Roth A., Spranger J., Stadler R., Steinberg P., Vieths S., Wätjen W., Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung, Journal of Consumer Protection and Food Safety, July 22, 2022, DOI: 10.1007/s00003-022-01386-w

Rebhahn V.I.Ch., Kiss E., Marko D., Del Favero G., Foodborne compounds that alter plasma membrane architecture can modify the response of intestinal cells to shear stress in vitro, Toxicology and Applied Pharmacology, Volume 446, 1 July 2022, DOI: 10.1016/j.taap.2022.116034

Gao J., Wenderoth M., Doppler M., Schuhmacher R., Marko D., Fischer R., Fungal Melanin Biosynthesis Pathway as Source for Fungal Toxins, ASM Journals mBio, June 28, 2022, DOI: 10.1128/mbio.00219-22

Groestlinger J., Seidl C., Varga E., Del Favero G., Marko D., Combinatory Exposure to Urolithin A, Alternariol, and Deoxynivalenol Affects Colon Cancer Metabolism and Epithelial Barrier Integrity in vitro, Frontiers in Nutrition, June 24, 2022, DOI: 10.3389/fnut.2022.882222

Castejón N., Marko D., Fatty Acid Composition and Cytotoxic Activity of Lipid Extracts from Nannochloropsis gaditana Produced by Green Technologies, molecules, June 9, 2022, DOI: 10.3390/molecules27123710

Eisenbrand G., Baum M., Cartus A.T., Diel P., Engel K-H., Engeli B., Epe B., Grune T., Guth S., Haller D., Heinz V., Hellwig M., Hengstler J.G., Henle Th., Humpf H-U., Jäger H., Joost H-G., Kulling S., Lachenmeier D.W., Lampen A., Leist M., Mally A., Marko D., Nöthlings U., Röhrdanz E., Roth A., Spranger J., Stadler R., Vieths S., Wätjen W., Steinberg P., Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis, Archives of Toxicology, June, 2022, DOI: 10.1007/s00204-022-03296-0

Groestlinger J., Spindler V., Pahlke G., Rychlik M., Del Favero G., Marko D., Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells, ACS Chemical Research in Toxicology, May 2022, DOI: 10.1021/acs.chemrestox.1c00364

Crudo F., Aichinger G., Dellafiora L., Kiss E., Mihajlovic J., Del Favero G., Berry D., Dall’Asta Ch., Marko D., Persistence of the antagonistic effects of a natural mixture of Alternaria mycotoxins on the estrogen-like activity of human feces after anaerobic incubation, Toxicology Letters, Vol 358, April 2022, DOI: 10.1016/j.toxlet.2022.01.015

Beisl J., Pahlke G., Ehling-Schulz M., Del Favero G., Marko D., Cereulide and Deoxynivalenol Increase LC3 Protein Levels in HepG2 Liver Cells, Toxins, Feb. 18, 2022, DOI: 10.3390/toxins14020151

Aichinger G., Grgic D., Beisl J., Crudo F., Warth B., Varga E., Marko D., N-acetyl cysteine alters the genotoxic and estrogenic properties of Alternaria toxins in naturally occurring mixtures, Emerging Contaminants, Vol 8, Pages 30-38, Jan. 3, 2022, DOI: 10.1016/j.emcon.2021.12.004

Braun D., Abia W.A., Šarkan B., Sulyok M., Waldhoer Th., Erber A.C., Krska R., Turner P.C., Marko D., Ezekiel, C.N. Warth B., Mycotoxin-mixture assessment in mother-infant pairs in Nigeria: From mothers' meal to infants’ urine, Chemosphere, Jan 2022, DOI: 10.1016/j.chemosphere.2021.132226

Del Favero G., Aichinger G., Hohenbichler J., Marko D., Dall’Asta Ch., Dellafiora L., A target fishing study to spot possible biological targets of fusaric acid: Inhibition of protein kinase-A and insights on the underpinning mechanisms, Food and Chemical Toxicology, Jan 2022, DOI: 10.1016/j.fct.2021.112663

Flasch M., Bueschl Ch., Del Favero G., Adam G., Schuhmacher R., Marko D., Warth B., Elucidation of xenoextrogen metabolism by non-targeted, stable isotope-assisted mass spetremotry in breast cancer cells, Environmental International, volume 158, Jan 2022, DOI: 10.1016/j.envint.2021.106940

2021

Grgic D., Varga E., Novak B., Müller A., Marko D., Isoflavones in Animals: Metabolism and Effects in Livestock and Occurrence in Feed, Toxins, 24. November 2021, DOI: 10.3390/toxins13120836

Boulos J.C., Saeed M.E.M.,Chatterjee M., Bülbül Y., Crudo F., Marko D., Munder M., Klauck S.M.,Efferth Th., Repurposing of the ALK Inhibitor Crizotinib for Acute Leukemia and Multiple Myeloma Cells, Pharmaceuticals, 14, Nov. 5, 2021, DOI: 10.3390/ph14111126

Cenk E., Schmutz C., Pahlke G., Oertel A., Kollarova J., Mock H-P., Matros A., Marko D., Immunomodulatory Properties of Blackberry Anthocyanins in THP-1 Derived Macrophages, International Journal of Molecular Sciences, Sept. 28, 2021, 22(19), 10483; DOI: 10.3390/ijms221910483

Aichinger G., Del Favero G., Warth B., Marko D., Alternaria toxins-Still emerging? Comprehensive Reviews in Food Science and Food Safety, 2021 Sept. doi: 10.1111/1541-4337.12803.

Pahlke G., Ahlberg K., Oertel A., Janson-Schaffer Th., Grabher S., Mock H-P., Matros A., Marko D., Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships, Molecular Nutrition & Food Research, 2021 Sept.;e2100229. doi: 10.1002/mnfr.202100229.

Guth S., Hüser S., Roth A., Degen G., Diel P., Edlund K., Eisenbrand G., Engel K-H., Epe B., Grune T., Heinz V., Henle Th., Humpf H-U., Jäger H., Joost H.-G., Kulling S. E., Lampen A., Mally A., Marchan R., Marko D., Mühle E., Nitsche M.A., Röhrdanz E., Stadler R., van Thriel Ch., Vieths S., Vogel R. F., Wascher E., Watzl C., Nöthlings U., Hengstler J. G.,Contribution to the ongoing discussion on fluoride toxicity, Archives of Toxicology, 2021 July. doi: 10.1007/s00204-021-03072-6.

Crudo F., Aichinger G., Mihajlovic J., Varga E., Dellafiora L., Warth B., Dall'Asta Ch., Berry D., Marko D., In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship, Archives of Toxicology, 2021 July, doi: 10.1007/s00204-021-03043-x

Aichinger G., Bliem G., Marko D., Systemically Achievable Doses of Beer Flavonoids Induce Estrogenicity in Human Endometrial Cells and Cause Synergistic Effects With Selected Pesticides, frontiers in Nutrition, 07 June 2021, DOI: 10.3389/fnut.2021.691872

Del Favero G., Janker L., Neuditschko B., Hohenbichler J., Kiss E., Woelflingseder L., Gerner Ch., Marko D., Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function, Archives of Toxicology, 2021 June, doi: 10.1007/s00204-021-03042-y

Del Favero G., Zeugswetter M., Kiss E., Marko D., Endoplasmic Reticulum Adaptation and Autophagic Competence Shape Response to Fluid Shear Stress in T24 Bladder Cancer Cells, frontiers in Pharmacology, 03 May 2021, DOI: 10.3389/fphar.2021.647350

Beisl J., Varga E., Braun D., Warth B., Ehling-Schulz M., Del Favero G., Marko D., Assessing Mixture Effects of Cereulide and Deoxynivalenol on Intestinal Barrier Integrity and Uptake in Differentiated Human Caco-2 Cells, Toxins, 2021 March 4, DOI: 10.3390/toxins13030189

2020

Groh I.A.M., Riva A., Braun D., Sutherland H.G., Williams O., Bakuradze T., Pahlke G., Richling E., Haupt L.M., Griffiths L.R., Berry D., Marko D., Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males, Antioxidants (Basel), 2020 Dec 29;10(1):E27. doi: 10.3390/antiox10010027

Guth S., Roth A., Engeli B., Lachenmeier D. W., Cartus A. T., Hüser S., Baum M., Diel P., Eisenbrand G., Hengstler J. G., Humpf H.-U., Joost H.-G., Lampen A., Leist M., Marko D., Steinberg P., Mally A., Zarn J. A., Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents, Food and Chemical Toxicology, 2020 Dec.;146:111784. doi: 10.1016/j.fct.2020.111784.

Aichinger G., Živná N., Varga E., Crudo F., Warth B., Marko D., Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins, Mycotoxin Research, 2020 Nov. doi: 10.1007/s12550-020-00405-9.

Braun D., Eiser M., Puntscher H., Marko D., Warth B., Natural Contaminants in Infant Food: The Case of Regulated and Emerging Mycotoxins, Food Control, Oct. 2020, DOI:10.1016/j.foodcont.2020.107676

Crudo F., Aichinger G., Mihajlovic J., Dellafiora L., Varga E., Puntscher H., Warth B., Dall'Asta C., Berry D., Marko D., Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro, Archives of Toxicology, 2020 Oct;94(10):3541-3552. doi: 10.1007/s00204-020-02831-1.

Braun D., Schernhammer E., Marko D., Warth B., Longitudinal Assessment of Mycotoxin Co-Exposures in Exclusively Breastfed Infants, Environment International, 2020 Sep.;142:105845. doi: 10.1016/j.envint.2020.105845.

Woelflingseder L., Adam G., Marko D., Suppression of Trichothecene-Mediated Immune Response by the Fusarium Secondary Metabolite Butenolide in Human Colon Epithelial Cells, Frontiers of Nutrition, 2020 Aug 6;7:127. doi: 10.3389/fnut.2020.00127

Hohenbichler J., Aichinger G., Rychlik M., Del Favero G., Marko D., Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro, Biomolecules 2020, 10(7), 1018, July 9, 2020, DOI: 10.3390/biom10071018

Juère E., Del Favero G., Masse F., Marko D., Popat A., Florek J., Caillard R., Kleitz F., Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: in vitro release, cytotoxicity and mitochondrial activity, European Journal of Pharmaceutics and Biopharmaceutics, 2020 June. pii: S0939-6411(20)30082-5. doi: 10.1016/j.ejpb.2020.03.015.

Aichinger G., Dellafiora L., Pantazi F., Del Favero G., Galaverna G., Dall'Asta C., Marko D., Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study, Archives of Toxicology, 2020 June, doi: 10.1007/s00204-020-02746-x

Groh I., Bakuradze T., Pahlke G., Richling E., Marko D., Consumption of Anthocyanin-Rich Beverages Affects Nrf2 and Nrf2-dependent Gene Transcription in Peripheral Lymphocytes and DNA Integrity of Healthy Volunteers, BMC Chemistry, 2020 May 29;14(1):39. doi: 10.1186/s13065-020-00690-6.

Braun D., Ezekiel Ch. N., Marko D., Warth B., Exposure to Mycotoxin-Mixtures via Breast Milk: An Ultra-Sensitive LC-MS/MS Biomonitoring Approach, Frontiers in Chemistry, May 2020, DOI: 10.3389/fchem.2020.00423.

Guth S., Hüser S., Roth A., Degen G., Diel P., Edlund K., Eisenbrand G., Engel K.H., Epe B., Grune T., Heinz V., Henle T., Humpf H.U., Jäger H., Joost H.G., Kulling S.E., Lampen A., Mally A., Marchan R., Marko D., Mühle E., Nitsche M.A., Röhrdanz E., Stadler R., Thriel C.v., Vieths S., Vogel R.F., Wascher E., Watzl C., Nöthlings U., Hengstler J.G., Toxicity of Fluoride: Critical Evaluation of Evidence for Human Developmental Neurotoxicity in Epidemiological Studies, Animal Experiments and in Vitro Analyses, Archives of Toxicology, 2020 May, doi: 10.1007/s00204-020-02725-2

Juère E., Caillard R., Marko D., Del Favero G., Kleitz F., Smart protein-based formulation of dendritic mesoporous silica nanoparticles: Toward oral delivery of insulin, Chemistry, 2020 Apr. 21. doi: 10.1002/chem.202000773

Woelflingseder L., Gruber N., Adam G., Marko D., Pro-Inflammatory Effects of NX-3 Toxin Are Comparable to Deoxynivalenol and not Modulated by the Co-Occurring Pro-Oxidant Aurofusarin, Microorganisms, 2020 Apr 21;8(4). pii: E603. doi: 10.3390/microorganisms8040603

Flasch M., Bueschl Ch., Woelflingseder L., Schwartz-Zimmermann H.E., Adam G., Schuhmacher R., Marko D., Warth B. Stable isotope-assisted metabolomics for deciphering xenobiotic metabolism in mammalian cell culture, ACS Chemical Biology, 2020 Apr 17, doi: 10.1021/acschembio.9b01016

Aichinger G., Lichtenberger F.B., Steinhauer T.N., Flörkemeier I., Del Favero G., Clement B., Marko D., The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties, Molecules. 2020 Mar 27;25(7). pii: E1524. doi: 10.3390/molecules25071524.

Del Favero G., Mayer R.M., Dellafiora L., Janker L., Niederstaetter L., Dall'Asta C., Gerner C., Marko D., Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol, Cells, 2020 Mar 31;9(4). pii: E847. doi: 10.3390/cells9040847.

Schrenk D., Bignami M., Bodin L., Chipman J. K., Del Mazo J., Grasl-Kraupp B., Hogstrand Ch., Hoogenboom L. R., Jean‐Charles Leblanc J-Ch., Nebbia C. S., Nielsen E., Ntzani E.,Petersen A., Sand S., Schwerdtle T., Vleminckx Ch., Marko D., Oswald I. P., Piersma A., Routledge M., Schlatter J., Baert K., Gergelova P., Wallace H., Risk assessment of aflatoxins in food, March 2020, EFSA Journal, 18(3)DOI: 10.2903/j.efsa.2020.6040

Beisl J., Pahlke G., Abeln H., Ehling-Schulz M., Del Favero G., Varga E., Warth B., Sulyok M., Abia W., Ezekiel CN., Marko D., Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells, Archives of Toxicology, 2020 March, doi: 10.1007/s00204-020-02658-w

Jank B., Rath J., Marko D., Vejdovszky K., Rauscher-Gabernig E., Exploring the TTC approach as a basis for risk management: The example of emerging Alternaria mycotoxins, Toxicology Letters, March 2020. pii: S0378-4274(19)30384-4. doi: 10.1016/j.toxlet.2019.11.027

Del Favero G., Hohenbichler J., Mayer R.M., Rychlik M., Marko D., Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages, Chemical Research in Toxicology, 2020 Feb, doi: 10.1021/acs.chemrestox.9b00378

Aichinger G., Pantazi F., Marko D., Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells, Toxicology Letters, Feb 2020. pii: S0378-4274(19)30350-9. doi: 10.1016/j.toxlet.2019.10.025

Puntscher H., Marko D., Warth B., First determination of the highly genotoxic fungal contaminantaltertoxin II in a naturally infested apple sample, Emerging Contaminants, Volume 6, 2020, Pages 82-86, January 2020, doi.org/10.1016/j.emcon.2020.01.002

2019

Crudo F., Varga E., Aichinger G., Galaverna G., Marko D., Dall'Asta C., Dellafiora L., Co-Occurrence and Combinatory Effects of Alternaria Mycotoxins and other Xenobiotics of Food Origin: Current Scenario and Future Perspectives, Toxins (Basel), 2019 Nov 3;11(11). pii: E640. doi: 10.3390/toxins11110640

Puntscher H., Aichinger G., Grabher S., Attakpah E., Krüger F., Tillmann K., Motschnig T., Hohenbichler J., Braun D., Plasenzotti R., Pahlke G., Höger H., Marko D., Warth B., Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats, Archives of Toxicology, 2019 Nov. doi: 10.1007/s00204-019-02575-7

Warth B. , Preindl K., Manser P., Wick P., Marko D., Buerki-Thurnherr T., Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta, Environmental Health Perspectives, 2019 Oct;127(10):107004. doi: 10.1289/EHP4860

Schmutz C., Cenk E., Marko D., The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL-1β-stimulated, Differentiated Caco-2 Cells, Molecular Nutrition & Food Research, 2019 Oct 4:e1900341. doi: 10.1002/mnfr.201900341

Aichinger G., Krüger F., Puntscher H., Preindl K., Warth B., Marko D., Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro, Archives of Toxicology, 2019 Oct. doi: 10.1007/s00204-019-02545-z

Costa J.G., Vidovic B., Saraiva N., do Céu Costa M., Del Favero G., Marko D., Oliveira N.G., Fernandes A.S., Contaminants: a dark side of food supplements? Free Radical Research, 2019 Sep 10:1-23. doi: 10.1080/10715762.2019.1636045

Preindl K., Braun D., Aichinger G., Sieri S,, Fang M., Marko D., Warth B., A Generic Liquid Chromatography-Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices, Analytical Chemistry, 2019 Sep 3;91(17):11334-11342. doi: 10.1021/acs.analchem.9b02446

Del Favero G., Bialas F., Grabher S., Wittig A., Bräuer B., Gerthsen D., Echalier C., Kamalov M., Marko D., Becker CFW., Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus, Chemical Communications (Camb.), 2019 Aug 21;55(65):9649-9652. doi: 10.1039/c9cc02215e

Puntscher H., Cobankovic I., Marko D., Warth B., Quantitation of free and modified Alternaria mycotoxins in European food products by LC-MS/MS, Food Control, Aug 2019, DOI:10.1016/j.foodcont.2019.03.019

Puntscher H., Marko D., Warth B., The Fate of Altertoxin II During Tomato Processing Steps at a Laboratory Scale, Frontiers in Nutrition, 2019 Jun 13;6:92. doi: 10.3389/fnut.2019.00092. eCollection 2019

Stadler D., Lambertini F., Woelflingseder L., Schwartz-Zimmermann H., Marko D., Suman M., Berthiller F., Krska R., The Influence of Processing Parameters on the Mitigation of Deoxynivalenol during Industrial Baking, Toxins / Basel, 2019 Jun 4;11(6). pii: E317. doi: 10.3390/toxins11060317

Bakuradze T., Tausend A., Galan J., Groh I., Berry D., Tur J.A., Marko D., Richling E., Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers, Free Radical Research, 2019 Jun 4:1-11. doi: 10.1080/10715762.2019.1618851

Woelflingseder L., Warth B., Vierheilig I., Schwartz‑Zimmermann H., Hametner C., Nagl V., Novak B., Šarkanj B., Berthiller F., Adam G., Marko D., The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol, Archives of Toxicology, 2019 May 2. doi: 10.1007/s00204-019-02459-w

Hochkogler C.M., Schweiger K., Rust P., Pignitter M., Rathmayr J., Bayer S., Chmelirsch Ch., Hüller l., Marko D., Lang R., Hofmann Th., Kurz A.Ch., Bytoff G., Lantz I., Schipp D., Somoza V., Daily consumption of a dark-roast coffee for eight weeks improved plasma oxidized LDL and alpha-tocopherol status: A randomized, controlled human intervention study, Journal of Functional Foods, Volume 56, May 2019, doi.org/10.1016/j.jff.2019.02.009

Lorenz N., Dänicke S., Edler L., Gottschalk C., Lassek E., Marko D., Rychlik M., Mally A., A critical evaluation of health risk assessment of modified mycotoxins with a special focus on zearalenone, Mycotoxin Research, 2019 Feb;35(1):27-46. doi: 10.1007/s12550-018-0328-z

Pahlke G., Attakpah E., Aichinger G., Ahlberg K., Hochkogler C.M., Schweiger K., Schipp D., Somoza V., Marko D., Dark coffee consumption protects human blood cells from spontaneous DNA damage, Journal of Functional Foods 55, Feb. 19, DOI: 10.1016/j.jff.2019.02.008

Puntscher H., Hankele S., Tillmann K., Attakpah E., Braun D., Kütt M.-L., Del Favero G., Aichinger G., Pahlke G., Höger H., Marko D., Warth B., First insights into Alternaria multi-toxin in vivo metabolism, Toxicology Letters, Feb. 2019, pii: S0378-4274(18)31989-1. doi: 10.1016/j.toxlet.2018.10.006

Dellafiora L., Aichinger G., Geib E., Sánchez-Barrionuevo L., Brock M., Cánovas D., Dall'Asta C., Marko D., Hybrid in silico/in vitro target fishing to assign function to "orphan" compounds of food origin - The case of the fungal metabolite atromentin, Food Chemistry, 2019 Jan 1;270:61-69. doi: 10.1016/j.foodchem.2018.07.027.

Schroeter A., Aichinger G., Stornig K., Marko D., Impact of Oxidative Metabolism on the Cytotoxic and Genotoxic Potential of Genistein in Human Colon Cancer Cells, Molecular Nutrition & Food Research, 2019 Jan;63(2):e1800635. doi: 10.1002/mnfr.201800635

2018

Del Favero G., Zaharescu R., Marko D., Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction, Archives of Toxicology, Dec. 2018, doi.org/10.1007/s00204-018-2317-6

Woelflingseder L., Del Favero G., Blažević T., Heiss E.H., Haider M., Warth B., Adam G., Marko D., Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells, Toxicology Letters, 2018 Dec 15;299:104-117. doi: 10.1016/j.toxlet.2018.09.007

Braun D., Ezekiel C.N., Abia W.A., Wisgrill L., Degen G.H., Turner P.C., Marko D., Warth B., Monitoring early-life mycotoxin exposures via LC-MS/MS breast milk analysis, Analytical Chemistry, 2018 Dec., doi: 10.1021/acs.analchem.8b04576

Kollarova J., Cenk E., Schmutz C., Marko D., The mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation in THP-1 derived macrophages targeting the NF-κB signalling pathway, Archives of Toxicology, 2018 Nov, doi: 10.1007/s00204-018-2299-4.

Del Favero G., Woelflingseder L., Braun D., Puntscher H., Kütt ML., Dellafiora L., Warth B., Pahlke G., Dall'Asta C., Adam G., Marko D., Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates, Toxicology Letters, 2018 Oct 1;295:424-437. doi: 10.1016/j.toxlet.2018.07.007

Aichinger G., Beisl J., Marko D., The Hop Polyphenols Xanthohumol and 8-Prenyl-Naringenin Antagonize the Estrogenic Effects of Fusarium Mycotoxins in Human Endometrial Cancer Cells, frontiers in Nutrition, 19 September 2018, doi.org/10.3389/fnut.2018.00085

Hüser S., Guth S., Joost H.G., Soukup S.T., Köhrle J., Kreienbrock L., Diel P., Lachenmeier D.W., Eisenbrand G., Vollmer G., Nöthlings U., Marko D., Mally A., Grune T., Lehmann L., Steinberg P., Kulling S.E., Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation, Archives of Toxicology, 2018 Sep, doi: 10.1007/s00204-018-2279-8.

Del Favero G., Woelflingseder L., Janker L., Neuditschko B., Seriani S., Gallina P., Sbaizero O., Gerner C., Marko D., Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation, Scientific Reports, 2018 Jul 27;8(1):11351. doi: 10.1038/s41598-018-29728-5.

Miklosi A.G., Del Favero G., Marko D., Harkany T., Lubec G., Resolution matters: Correlating quantitative proteomics and nanoscale‐precision microscopy for reconstructing synapse identity2, Proteomics, Jul 18, 2018, doi.org/10.1002/pmic.201800139

Puntscher H., Kütt M-L., Skrinjar P., Mikula H., Podlech J., Fröhlich J., Marko D., Warth B., Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins, Analytical and Bioanalytical Chemistry, 2018 Jul 18, doi: 10.1007/s00216-018-1105-8.

Dellafiora L., Warth B., Schmidt V., Del Favero G., Mikula H., Fröhlich J., Marko D., An integrated in silico/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites, Food Chemistry, 2018 May 15;248:253-261. doi: 10.1016/j.foodchem.2017.12.013.

Varga E., Wiesenberger G., Woelflingseder L., Twaruschek K., Hametner C., Vaclaviková M., Malachová A., Marko D., Berthiller F., Adam G., Less-toxic rearrangement products of NX-toxins are formed during storage and food processing, Toxicology Letters, 2018 Mar 1;284:205-212. doi: 10.1016/j.toxlet.2017.12.016.

Jarolim K., Wolters K., Woeflingseder L., Pahlke G., Beisl J., Puntscher H., Braun D., Sulyok M., Warth B., Marko D., The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells, Toxicology Letters, 2018 Mar 1;284:170-183. doi: 10.1016/j.toxlet.2017.12.008.

Aichinger G., Puntscher H., Beisl J., Kütt M.L., Warth B., Marko D., Delphinidin protects colon carcinoma cells against the genotoxic effects of the mycotoxin altertoxin II, Toxicology Letters, 2018 Mar 1;284:136-142. doi: 10.1016/j.toxlet.2017.12.002.

2017

Abia W.A., Warth B., Ezekiel C. N., Sarkanj B., Turner P. C., Marko D., Krska R., Sulyok M., Uncommon toxic microbial metabolite patterns in traditionally home-processed maize dish (fufu) consumed in rural Cameroon, Food and Chemical Toxicology, Volume 107, Part A, September 2017, Pages 10-19, doi.org/10.1016/j.fct.2017.06.011

Miklosi A.G., Del Favero G., Bulat T., Höger H., Shigemoto R., Marko D., Lubec G., Super-resolution Microscopical Localization of Dopamine Receptors 1 and 2 in Rat Hippocampal Synaptosomes, Molecular Neurobiology 2017 Jun, doi: 0.1007/s12035-017-0688-y

Jarolim K., Del Favero G., Ellmer D., Stark T.D., Hofmann Th., Sulyok M., Humpf H.U., Marko D., Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase, Archives of Toxicology, 2017 Apr, DOI 10.1007/s00204-016-1855-z

Tiessen C., Ellmer D., Mikula H., Pahlke G., Warth B., Gehrke H., Zimmermann K., Heiss E., Fröhlich J., Marko D., Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells, Archives of Toxicology 2017 Mar;91(3):1213-1226. doi: 10.1007/s00204-016-1801-0.

Meier C., Steinhauser TN., Koczian F., Plitzko B., Jarolim K., Girreser U., Braig S., Marko D., Vollmar AM., Clement B., A Dual Topoisomerase Inhibitor of Intense Pro-Apoptotic and Antileukemic Nature for Cancer Treatment, ChemMedChem 2017 Mar 7, doi: 10.1002/cmdc.201700026.

Vejdovszky K., Schmidt V., Warth B, Marko D., Combinatory estrogenic effects between the isoflavone genistein and the mycotoxins zearalenone and alternariol in vitro. Molecular Nutrition & Food Research, 2017 Mar, doi: 10.1002/mnfr.201600526.

Vejdovszky K., Hahn K., Braun D., Warth B., Marko D., Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro, Archives of Toxicology, Mar 2017, DOI 10.1007/s00204-016-1795-7

Aichinger G., Beisl J., Marko D., Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells, Molecular Nutrition & Food Research 2017 Feb;61(2). doi: 10.1002/mnfr.201600462

Vejdovszky K., Sack M., Jarolim K., Aichinger G., Somoza MM., Marko D., In vitro combinatory effects of the Alternaria mycotoxins alternariol and altertoxin II and potentially involved miRNAs. Toxicology Letters, Feb 5, 267: 45-52, doi: 10.1016/j.toxlet.2016.12.011.

Wittig, A., Gehrke, H., Del Favero, G., Fritz, E.-M., Al-Rawi, M., Diabaté, S., Weiss, C., Sami, H., Ogris, M., Marko D., Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells. Nanomaterials 2017, Jan 13, 7, 18; doi:10.3390/nano7010018

Jarolim K., Del Favero G., Pahlke G., Dostal V., Zimmermann K., Heiss E., Ellmer D., Stark T.D., Hofmann T., Marko D., Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II, Archives of Toxicology, 2017 Jan, DOI 10.1007/s00204-016-1726-7

2016

Groh I., Rudakovski O., Gründken M., Schroeter A., Marko D., Esselen M., Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases, Archives of Toxicology, Nov. 2016, DOI 10.1007/s00204-015-1625-3

Marko D., Boege F., A possible link between nutritional uptake of ubiquitous topoisomerase inhibitors and autism? Commentary International Journal of Developmental Neuroscience, Volume 53, Oct. 2016, Pages 8–9, 2016 Oct.;53:8-9. doi: 10.1016/j.ijdevneu.2016.06.003.

Clement B., Girreser U., Steinhauer T.N., Meier Ch., Marko D., Aichinger G., Kaltefleiter I., Stenzel L., Heber D., Weide M., Wolschendorf U., Zebothsen I., Zur Nieden D., 11-Substituted Benzo[c]phenanthridines: New Strucutres and Insight into Their Mode of Antiproliferative Action, ChemMedChem, 2016 Oct 6, doi: 10.1002/cmdc.201600199

Warth B., Del Favero G., Wiesenberger G., Puntscher H., Woelflingseder L., Fruhmann P., Sarkanj B., Krska R., Schuhmacher R., Adam G., Marko D., Identification of a novel humen deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells, Scientific Reports 2016 Sep 23; 6:33854. doi: 10.1038/srep33854

Seriani S., Del Favero G., Mahaffey J., Marko D., Gallina P., Long C. S., Mestroni L., Sbaizero O., The cell-stretcher: A novel device for the mechanical stimulation of cell populations, Review of Scientific Instruments 87, 2016 Aug, 084301 (2016); doi: 10.1063/1.4959884

Aichinger G., Pahlke G., Nagel L. J., Berger W., Marko D., Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells, Food and function, 2016 Aug 10;7(8):3628-3636, DOI: 10.1039/c6fo00570e

Warth B., Braun D., Ezekiel Ch.N., Turner P.C., Degen G.H., Marko D., Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives, Chemical Research in Toxicology, July 18th 2016, doi: 10.1021/acs.chemrestox.6b00125

Baechler S.A., Soukup S.T., Molzberger A.F., Kulling S.E., Diel P., Marko D., Topoisomerase poisoning by genistein in the intestine of rats, Toxicology Letters, 2016 Jan 22;243:88-97. doi: 10.1016/j.toxlet.2015.12.009

Vejdovszky K., Warth B., Sulyok M., Marko D., Non-synergistic cytotoxic effects of Fusarium and Alternaria toxin combinations in Caco-2 cells, Toxicology Letters, Oct. 2015. doi: 10.1016/j.toxlet.2015.10.024

Peukert M., Thiel J., Mock H.P., Marko D., Weschke W., Matros A., Spatiotemporal Dynamics of Oligofructan Metabolism and Suggested Functions in Developing Cereal Grains, Frontiers in plant science, Jan 19 2016, doi: 10.3389/fpls.2015.01245

Pahlke G., Tiessen C., Domnanich K., Kahle N., Groh I.A.M., Schreck I., Weiss C., Marko D., Impact of Alternaria toxins on CYP1A1 expression in different human tumor cells and relevance for genotoxicity, Toxicology Letters, 2016 Jan 5;240(1):93-104. doi: 10.1016/j.toxlet.2015.10.003

2015

Schroeter A., Groh I., Del Favero G., Pignitter M., Schueller K., Somoza V., Marko D., Inhibition of topoisomerase II by phase II metabolites of RSV in human colon cancer cells. Molecular Nutrition & Food Research, Dec. 2015. doi: 10.1002/mnfr.201500352

Rohm B., Holik A-K., Kretschy N., Somoza M.M., Ley J.P., Widder S., Krammer G.E., Marko D., Somoza V., Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PRARy expression in 3T3-L1 cells, Journal of Cellular Biochemistry, Jun. 2015, DOI: 10.1002/jcb.25052

Habermeyer M., Roth A., Guth S., Diel P., Engel K.H., Epe B., Furst P., Heinz V., Humpf H.U., Joost H.G., Knorr D., De Kok T., Kulling S., Lampen A., Marko D., Rechkemmer G., Rietjens I., Stadler R.H., Vieths S., Vogel R., Steinberg P., and Eisenbrand G., Nitrate and nitrite in the diet: How to assess their benefit and risk for human health, Molecular Nutrition & Food Research, Jan 2015, 59, 106-128, DOI: 10.1002/mnfr.201400286

2014

Schroeter A., Marko D., Resveratrol Modulates the Topoisomerase Inhibitory Potential of Doxorubicin in Human Colon Carcinoma Cells, Molecules, Dec 2014, 19, 20054-20072; doi:10.3390/molecules191220054

Rychlik M., Humpf H-U., Marko D., Dänicke S., Mally A., Berthiller F., Klaffke H., Lorenz N., Proposal of a comprehensive definition of modified and other forms of mycotoxins including "masked" mycotoxins. Mycotoxin Research, Volume 4, Nov 2014, Pages 197-205; DOI: 10.1007/s12550-014-0203-5

Winkler S., Dieminger N., Blust V., Riedel A., Bakuradze T., Montoya G., Hassmann U., Lang R., Hofmann T., Somoza V., Richling E., Bytof G., Stiebitz H., Lantz I., Schipp D., Raedle J., Marko D., Modulation of inflammatory gene transcription after long-term coffee consumption, Food Research International, Volume 63 / Part C, September 2014, Pages 428–438, DOI: 10.1016/j.foodres.2014.05.073

Hassmann U., Haupt L.M., Smith R.A., Winkler S., Bytof G., Lantz I., Griffiths L.R., Marko D., Potential antioxidant response to coffee – A matter of genotype? Meta Gene, Volume 2, Aug 2014, Pages 525-539, DOI: 10.1016/j.mgene.2014.07.003

Riedel A., Dieminger N., Bakuradze T., Lang R., Montoya G., Hochkogler C.M., Winkler S., Bytof G., Lantz I., Stiebitz H., Richling E., Hofmann T., Marko D., Schipp D., Raedle J., Somoza V., A 4-week consumption of medium roast and dark roast coffee affects parameters of energy status in healthy subjects, Food Research International, 63:409-419 · September 2014, DOI: 10.1016/j.foodres.2014.04.002

Bakuradze T., Montoya Parra G., Riedel A., Somoza V., Lang R., Dieminger N., Hofmann T., Winkler S., Hassmann U., Marko D., Schipp D., Raedle J., Bytof G., Lantz I., Stiebitz H., Richling E., Four weeks coffee consumption affects energy intake, satiety regulation, body fat, and protects DNA integrity, Food Research International, Volume 63, Part C, September 2014, Pages 420–427DOI: 10.1016/j.foodres.2014.05.032

Blank H., Schneider R., Gerthsen D., Gehrke H., Jarolim K., Marko D., Application of low-energy scanning transmission electron microscopy for the study of Pt-nanoparticle uptake in human colon carcinoma cells, Nanotoxicology, 2014 Jun,8(4):433-46.

Baechler S.A., Schroeter A., Walker J., Aichinger G., Marko D., Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein, Molecular Nutrition & Food Research, 2014 Jun,58(6):1269-81. DOI: 10.1002/mnfr.201300531

Seiter J., Müller E., Blank H., Gehrke H., Marko D., Gerthsen D., Backscattered electron SEM imaging of cells and determination of the information depth, Journal of Microscopy 2014 May,254(2):75-83. DOI: 10.1111/jmi.12120

Baechler S.A., Schroeter A., Dicker M., Steinberg P., Marko D., Topoisomerase II-Targeting Properties of a Grapevine-Shoot Extract and Resveratrol Oligomers, Journal of Agricultural and Food Chemistry 2014 Jan 10. DOI: 10.1021/jf4046182

2013

Thiele W., Rothley M., Teller N., Jung N., Bulat B., Plaumann D., Vanderheiden S., Schmaus A., Cremers N., Göppert B., Dimmler A., Eschbach V., Quagliata L., Thaler S., Marko D., Bräse S., Sleeman J.P., Delphinidin is a novel inhibitor of lymphangiogenesis, but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis 2013 Dec,34(12):2804-13.

Tiessen C., Gehrke H., Kropat C., Schwarz C., Bächler S., Fehr M., Pahlke G., Marko D., Role of topoisomerase inhibition and DNA repair mechanisms in the genotoxicity of alternariol and altertoxin-II. World Mycotoxin Journal, August 2013, 6 (3): 233-244.

Kropat C., Betz M., Kulozik U., Leick S., Rehage H., Boettler U., Teller N., Marko D., Effect of microformulation on the bioactivity of an anthocyanin-rich bilberry pomace extract ( Vaccinium myrtillus L.) in vitro. Journal of Agricultural and Food Chemistry 2013 May 22,61(20):4873-81.

Gehrke H., Frühmesser A., Pelka J., Esselen M., Hecht L.L., Blank H., Schuchmann H.P., Gerthsen D., Marquardt C., Diabaté S., Weiss C., Marko D., In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. Nanotoxicology 2013 May,7(3):274-93.

Teller N., Roth M., Esselen M., Fridrich D., Boettler U., Blust V., Will F., Dietrich H., Raul F., Hümmer W., Richling E., Schreier P., Marko D., Apple procyanidins affect several members of the ErbB receptor tyrosine kinase family in vitro. Food & Function 2013 Apr 30,4(5):689-97.

Esselen M., Barth S.W., Winkler S., Baechler S., Briviba K., Watzl B., Skrbek S., Marko D., Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. Carcinogenesis 2013 Apr,34(4):835-40.

Kropat C., Mueller D., Boettler U., Zimmermann K., Heiss E.H., Dirsch V.M., Rogoll D., Melcher R., Richling E., Marko D., Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo. Molecular Nutrition & Food Research 2013 Mar,57(3):545-50.

Baechler S.A., Fehr M., Habermeyer M., Hofmann A., Merz K.H., Fiebig H.H., Marko D., Eisenbrand G., Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. Bioorganic & Medicinal Chemistry 2013 Feb 1,21(3):814-23.

Pelka J., Gehrke H., Rechel A., Kappes M., Hennrich F., Hartinger C.G., Marko D., DNA damaging properties of single walled carbon nanotubes in human colon carcinoma cells. Nanotoxicology 2013 Feb,7(1):2-20.

Tiessen C., Fehr M., Schwarz C., Baechler S., Domnanich K., Böttler U., Pahlke G., Marko D., Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether. Toxicology Letters 2013 Jan 10,216(1):23-30.

2012

Kurzwernhart A., Kandioller W., Bächler S., Bartel C., Martic S., Buczkowska M., Mühlgassner G., Jakupec M.A., Kraatz H.B., Bednarski P.J., Arion V.B., Marko D., Keppler B.K., Hartinger C.G. Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands. Journal of Medicinal Chemistry 2012 Dec 13,55(23):10512-22.

Schwarz C., Tiessen C., Kreutzer M., Stark T., Hofmann T., Marko D., Characterization of a genotoxic impact compound in Alternaria alternata infested rice as Altertoxin II. Archives of Toxicology 2012 Dec,86(12):1911-25.

Volz N., Boettler U., Winkler S., Teller N., Schwarz C., Bakuradze T., Eisenbrand G., Haupt L., Griffiths L.R., Stiebitz H., Bytof G., Lantz I., Lang R., Hofmann T., Somoza V., Marko D., Effect of Coffee Combining Green Coffee Bean Constituents with Typical Roasting Products on the Nrf2/ARE Pathway in Vitro and in Vivo. Journal of Agricultural and Food Chemistry 2012 Sep 26,60(38):9631-41.

Schwarz C., Kreutzer M., Marko D., Minor contribution of alternariol, alternariol monomethyl ether and tenuazonic acid to the genotoxic properties of extracts from Alternaria alternata infested rice. Toxicology Letters (2012) 214:46–52.

Boettler U., Volz N., Teller N., Haupt L.M., Bakuradze T., Eisenbrand G., Bytof G., Lantz I., Griffiths L.R., Marko D., Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype? Molecular Biology Reports 2012 Jun,39(6):7155-62.

Kurzwernhart A., Kandioller W., Bartel C., Bächler S., Trondl R., Mühlgassner G., Jakupec M.A., Arion V.B., Marko D., Keppler B.K., Hartinger C.G., Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder. Chemical Communications (Cambridge) 2012 May 18,48(40):4839-41.

Schreck I., Deigendesch U., Burkhardt B., Marko D., Weiss C., The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor. Archives of Toxicology 2012 Apr,86(4):625-32.

2011

Kotyczka C., Boettler U., Lang R., Stiebitz H., Bytof G., Lantz I., Hofmann T., Marko D., Somoza V., Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers. Molecular Nutrition & Food Research 2011, 55, (10), 1582-6.

Esselen M., Boettler U., Teller N., Bächler S., Hutter M., Rüfer C.E., Skrbek S., Marko D., Anthocyanin-Rich Blackberry Extract Suppresses the DNA-Damaging Properties of Topoisomerase I and II Poisons in Colon Carcinoma Cells. Journal of Agricultural and Food Chemistry 2011 Jul 13,59(13):6966-6973.

Gehrke H., Pelka J., Hartinger C.G., Blank H., Bleimund F., Schneider R., Gerthsen D., Bräse S., Crone M., Türk M., Marko D., Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations. Archives of Toxicology , 2011 Jul,85(7):799-812.

Kalfalah F.M., Mielke C., Christensen M.O., Baechler S., Marko D., Boege F., Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S127-42.

Boettler U., Volz N., Pahlke G., Teller N., Kotyczka C., Somoza V., Stiebitz H., Bytof G., Lantz I., Lang R., Hofmann T., Marko D., Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S143-53.

Esselen M., Fritz J., Hutter M., Teller N., Baechler S., Boettler U., Marczylo T.H., Gescher A.J., Marko D., Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells. Molecular Nutrition & Food Research 2011 May,55 Suppl 1:S143-53.

Boettler U., Sommerfeld K., Volz N., Pahlke G., Teller N., Somoza V., Lang R., Hofmann T., Marko D., Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. The Journal of Nutritional Biochemisty 2011 May,22(5):426-40

2010

Cai H., Marczylo T.H., Teller N., Brown K., Steward W.P., Marko D., Gescher A.J., Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase. European Journal of Cancer 2010, 46, (4), 811-7.

Barth S.W., Briviba K., Watzl B., Jager N., Marko D., Esselen M., In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats. Biotechnology Journal 2010, 5, (3), 321-7.

Fehr M., Baechler S., Kropat C., Mielke C., Boege F., Pahlke G., Marko D., Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1. Mycotoxin Research 2010, 26, (4), 247-256.

2009

Thomasset S., Teller N., Cai H., Marko D., Berry D.P., Steward W.P., Gescher A.J., Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? Cancer Chemotherapy and Pharmacology 2009, 64, (1), 201-11.

Teller N., Thiele W., Marczylo T.H., Gescher A.J., Boettler U., Sleeman J., Marko D., Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. Journal of Agricultural and Food Chemistry 2009, 57, (8), 3094-101.

Teller N., Thiele W., Boettler U., Sleeman J., Marko D., Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Molecular Nutrition & Food Research 2009, 53, (9), 1075-83.

Pelka J., Gehrke H., Esselen M., Turk M., Crone M., Brase S., Muller T., Blank H., Send W., Zibat V., Brenner P., Schneider R., Gerthsen D., Marko D., Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity. Chemical Research in Toxicology 2009, 22, (4), 649-59.

Marko D., Food-borne Mycotoxins. Molecular Nutrition & Food Research 2009, 53, (4), 421.

Fehr M., Pahlke G., Fritz J., Christensen M.O., Boege F., Altemoller M., Podlech J., Marko D., Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Molecular Nutrition & Food Research 2009, 53, (4), 441-51.

Esselen M., Fritz J., Hutter M., Marko D., Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons. Chemical Research in Toxicology 2009.

Skrbek S., Rufer C.E., Marko D., Esselen M., Quercetin and its microbial degradation product 3,4-dihydroxyphenylacetic acid generate hydrogen peroxide modulating their stability under in vitro conditions. Journal of Food and Nutrition Resesarch 2009, 48, (3), 129-140.

Dornetshuber R., Heffeter P., Lemmens-Gruber R., Elbling L., Marko D., Micksche M., Berger W., Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction. Molecular Nutrition & Food Research 53 (9):1112-22, 2009. 10.1002/mnfr.200800571

2008

Fritz J., Roth M., Holbach P., Esselen M., Marko D., Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 2008, 56, (19), 8891-6.

Fridrich D., Teller N., Esselen M., Pahlke G., Marko D., Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Molecular Nutrition & Food Research 2008, 52, (7), 815-22.

Fridrich D., Glabasnia A., Fritz J., Esselen M., Pahlke G., Hofmann T., Marko D., Oak ellagitannins suppress the phosphorylation of the epidermal growth factor receptor in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 2008, 56, (9), 3010-5.

2007

Kern M., Fridrich D., Reichert J., Skrbek S., Nussher A., Hofem S., Vatter S., Pahlke G., Rufer C., Marko D., Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. Molecular Nutrition & Food Research 2007, 51, (9), 1163-72.

Kern M., Pahlke G., Balavenkatraman K.K., Bohmer F.D., Marko D., Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 2007, 55, (13), 4999-5006.

Fridrich D., Kern M., Pahlke G., Volz N., Will F., Dietrich H., Marko D., Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells. Molecular Nutrition & Food Research 2007, 51, (5), 594-601.

Fridrich D., Kern M., Fritz J., Pahlke G., Kohler N., Winterhalter P., Marko D., The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins. Molecular Nutrition & Food Research 2007, 51, (2), 192-200.

2006

Pahlke G., Ngiewih Y., Kern M., Jakobs S., Marko D., Eisenbrand G., Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 2006, 54, (19), 7075-82.

Kern M., Pahlke G., Ngiewih Y., Marko D., Modulation of key elements of the Wnt pathway by apple polyphenols. Journal of Agricultural and Food Chemistry 2006, 54, (19), 7041-6.

Fritz J., Kern M., Pahlke G., Vatter S., Marko D., Biological activities of malvidin, a red wine anthocyanidin. Molecular Nutrition & Food Research 2006, 50, (4-5), 390-5.

2005

Puppel N., Tjaden Z., Fueller F., Marko D., DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells. Mutatation Research 2005, 580, (1-2), 71-80.

Kern M., Tjaden Z., Ngiewih Y., Puppel N., Will F., Dietrich H., Pahlke G., Marko D., Inhibitors of the epidermal growth factor receptor in apple juice extract. Molecular Nutrition & Food Research 2005, 49, (4), 317-28.

Habermeyer M., Fritz J., Barthelmes H. U., Christensen M. O., Larsen M. K., Boege F., Marko D., Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. Chemical Research in Toxicology 2005, 18, (9), 1395-404.

2004 - 1998

Marko D., Puppel N., Tjaden Z., Jakobs S., Pahlke G., The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Molecular Nutrition & Food Research 2004, 48, (4), 318-25.

Grant K. M., Dunion M. H., Yardley V., Skaltsounis A. L., Marko D., Eisenbrand G., Croft S. L., Meijer L., Mottram J. C., Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrobiagl Agents and Chemotherapy 2004, 48, (8), 3033-42.

Barthelmes H. U., Habermeyer M., Christensen M. O., Mielke C., Interthal H., Pouliot J. J., Boege F., Marko D., TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II. The Journal of Biological Chemistry 2004, 279, (53), 55618-25.

Marko D., Habermeyer M., Kemeny M., Weyand U., Niederberger E., Frank O., Hofmann T., Maillard reaction products modulating the growth of human tumor cells in vitro. Chemical Research in Toxicology 2003, 16, (1), 48-55.

Wagner B., Jakobs S., Habermeyer M., Hippe F., Cho-Chung Y. S., Eisenbrand G., Marko D., 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells. Biochemical Pharmacology 2002, 63, (4), 659-68.

Marko D., Merz K. H., Kunz C., Muller A., Tarasova N., Eisenbrand G., Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase. Biochemical Pharmacology 2002, 63, (4), 669-76.

Marko D., Kemeny M., Bernady E., Habermeyer M., Weyand U., Meiers S., Frank O., Hofmann T., Studies on the inhibition of tumor cell growth and microtubule assembly by 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione, an intensively coloured Maillard reaction product. Food and Chemical Toxicology 2002, 40, (1), 9-18.

Meiers S., Kemeny M., Weyand U., Gastpar R., von Angerer E., Marko D., The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. Journal of Agricultural and Food Chemistry2001, 49, (2), 958-62.

Marko D., Schatzle S., Friedel A., Genzlinger A., Zankl H., Meijer L., Eisenbrand G., Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. British Journal of Cancer 2001, 84, (2), 283-9.

Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J. A., Snyder G. L., Greengard P., Biernat J., Wu Y. Z., Mandelkow E. M., Eisenbrand G., Meijer L., Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of Biological Chemistry 2001, 276, (1), 251-60.

Davies T. G., Tunnah P., Meijer L., Marko D., Eisenbrand G., Endicott J. A., Noble M. E., Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure 2001, 9, (5), 389-97.

Barthelmes H. U., Niederberger E., Roth T., Schulte K., Tang W. C., Boege F., Fiebig H. H., Eisenbrand G., Marko D., Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells. British Journal of Cancer 2001, 85, (10), 1585-91.

Amara M. O., Franetich J. F., Bouladoux N., Mazier D., Eisenbrand G., Marko D., Meijer L., Doerig C., Desportes-Livage I., In vitro activity of antimitotic compounds against the microsporidium Encephalitozoon intestinalis. Journal Eukaryotic Microbiology 2001, Suppl, 99S-100S.

Marko D., Pahlke G., Merz K. H., Eisenbrand G., Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy. Chemical Research in Toxicology 2000, 13, (10), 944-8.

Hoessel R., Leclerc S., Endicott J. A., Nobel M. E., Lawrie A., Tunnah P., Leost M., Damiens E., Marie D., Marko D., Niederberger E., Tang W., Eisenbrand G., Meijer L., Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature Cell Biology 1999, 1, (1), 60-7.

Merz K. H., Marko D., Regiert T., Reiss G., Frank W., Eisenbrand G., Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth. Journal of Medicinal Chemistry 1998, 41, (24), 4733-43.

Marko D., Romanakis K., Zankl H., Furstenberger G., Steinbauer B., Eisenbrand G., Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts. Cell Biochemistry and Biophysics 1998, 28, (2-3), 75-101.

Gastpar R., Goldbrunner M., Marko D., von Angerer E., Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. Journal of Medicinal Chemistry 1998, 41, (25), 4965-72.