Giorgia Del Favero

Group Leader of Imaging & Biophysical Toxicology

Academic Career and Education

• Since 2022 Tenure Track Professor for Toxicology, University of Vienna, Faculty of Chemistry

• 2021 Habilitation (venia docendi)

• Since 2019 Head of the Core Facility Multimodal Imaging, University of Vienna, Faculty of Chemistry

• Since 09/2017 Senior Scientist at the Department of Food Chemistry and Toxicology, University of Vienna, Austria

• 10/2014-08/2017 PostDoc Research Assistant at the Department of Food Chemistry and Toxicology, University of Vienna, Austria

• 11/2012-09/2014 Post-doctoral fellowships University of Trieste, Department of Engineering and Architecture.  Evaluation of the consequences of pathological and toxicological processes in the mechanical properties of the cells

• 10/2013-01/2014 Visiting researcher at University of Arizona, Department of Physiology, Molecular Cardiovascular Research Program (Tucson, US). Marie Curie Actions—International Research Staff Exchange Scheme (IRSES). FP7-PEOPLE-2011-IRSES

• 01/2009-04/2012 PhD School Chemical and Pharmaceutical Sciences and Technologies of the University of Trieste. Project title: “Characterization of the risk of palytoxin and analogues as seafood contaminants”

• 10/2003-11/2008 Single cycle advanced degree Pharmaceutical Chemistry and Technology (5 years program) Faculty of Pharmacy, University of Trieste, Italy

Research

• Biomechanics

• Imaging

Publications (selection)

• 09/2022 Del Favero G., Jobst M., Kiss E., Marko D., P12-25 Response profile of bladder cells to environmental stressors: how modulation of autophagy reflects on biomechanical compliance, Toxicology Letters

• 04/2022 Crudo F., Aichinger G., Dellafiora L., Kiss E., Mihajlovic J., Del Favero G., Berry D., Dall’Asta Ch., Marko D., Persistence of the antagonistic effects of a natural mixture of Alternaria mycotoxins on the estrogen-like activity of human feces after anaerobic incubation, Toxicology Letters

• 02/2022 Bileck A., Bortel P., Kriz M., Janker L., Kiss E., Gerner Ch., Del Favero G., Inward Outward Signaling in Ovarian Cancer: Morpho-Phospho-Proteomic Profiling Upon Application of Hypoxia and Shear Stress Characterizes the Adaptive Plasticity of OVCAR-3 and SKOV-3 Cells, frontiers in Oncology

• 02/2022 Beisl J., Pahlke G., Ehling-Schulz M., Del Favero G., Marko D., Cereulide and Deoxynivalenol Increase LC3 Protein Levels in HepG2 Liver Cells, Toxins

• 02/2020 Beisl J., Pahlke G., Abeln H., Ehling-Schulz M., Del Favero G., Varga E., Warth B., Sulyok M., Abia W., Ezekiel CN., Marko D., Combinatory effects of cereulide and deoxynivalenol on in vitro cell viability and inflammation of human Caco-2 cells, Archives of Toxicology

• 02/2020 Juère E., Caillard R., Marko D., Del Favero G., Kleitz F., Smart protein-based formulation of dendritic mesoporous silica nanoparticles: Toward oral delivery of insulin, Chemistry

• 02/2020 Del Favero G., Hohenbichler J., Mayer R.M., Rychlik M., Marko D., Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages, Chemical Research in Toxicology

• 07/2019 Del Favero G., Bialas F., Grabher-Wusche S., Wittig A., Bräuer B., Gerthsen D., Echalier C., Kamalov M., Marko D., Becker Ch.F.W., Silica particles with a Quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus, Chemical Communications

• 06/2019 Wernitznig D., Kiakos K., Del Favero G., Harrer N., Machat H., Osswald A., Jakupec M.A., Wernitznig A., Sommergruber W., Keppler B.K., First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro. Metallomics

• 02/2019 Puntscher H., Hankele S., Tillmann K., Attakpah E., Braun D., Kütt M-L., Del Favero G., Aichinger G., Pahlke G., Höger H., Marko D., Warth B., First insights into Alternaria multi-toxin in vivo metabolism, Toxicology Letters

• 12/2018 Woelflingseder L., Del Favero G., Blažević T., Heiss E.H., Haider M., Warth B., Adam G., Marko D., Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells, Toxicology Letters

• 12/2018 Del Favero G., Zaharescu R., Marko D., Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction, Archives of Toxicology

• 10/2018 Del Favero G., Woelflingseder L., Braun D., Puntscher H., Kütt ML., Dellafiora L., Warth B., Pahlke G., Dall'Asta C., Adam G., Marko D., Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates, Toxicology Letters

• 07/2018 Del Favero G., Woelflingseder L., Janker L., Neuditschko B., Seriani S., Gallina P., Sbaizero O., Gerner C., Marko D., Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation, Scientific Reports

• 07/2018 Miklosi A.G., Del Favero G., Marko D., Harkany T., Lubec G., Resolution matters: Correlating quantitative proteomics and nanoscale‐precision microscopy for reconstructing synapse identity2, Proteomics

• 05/2018 Dellafiora L., Warth B., Schmidt V., Del Favero G., Mikula H., Fröhlich J., Marko D. An integrated in silico/in vitro approach to assess the xenoestrogenic potential of  Alternaria mycotoxins and metabolites, Food Chemistry

•  07/2017 Miklosi A.G., Del Favero G., Bulat T., Höger H., Shigemoto R., Marko D., Lubec G. Super-resolution Microscopical Localization of Dopamine Receptors 1 and 2 in Rat Hippocampal Synaptosomes, Molecular Neurobiology

• 04/2017 Jarolim K., Del Favero G., Ellmer D., Stark T.D., Hofmann Th., Sulyok M., Humpf H.U., Marko D. Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase, Archives of Toxicology

• 01/2017 Wittig, A., Gehrke, H., Del Favero, G., Fritz, E.-M., Al-Rawi, M., Diabaté, S., Weiss, C., Sami, H., Ogris, M., Marko D. Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells. Nanomaterials

• 01/2017 Jarolim K., Del Favero G., Pahlke G., Dostal V., Zimmermann K., Heiss E., Ellmer D., Stark TD., Hofmann T., Marko D. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II, Archives of Toxicology

• 09/2016 Warth B., Del Favero G., Wiesenberger G., Puntscher H., Woelflingseder L., Fruhmann P., Sarkanj B., Krska R., Schuhmacher R., Adam G., Marko D. Identification of a novel humen deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells, Scientific Reports

• 08/2016 Seriani S., Del Favero G., Mahaffey J., Marko D., Gallina P., Long C. S., Mestroni L., Sbaizero O. The cell-stretcher: A novel device for the mechanical stimulation of cell populations, Review of Scientific Instruments

• 12/2015 Perkin J., Slater R., Del Favero G., Lanzicher Th., Hidalgo C., Anderson B., Smith J.E., Sbaizero O., Labeit S., Granzier H. Phosphorylating Titin´s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force, Biophysical Journal

• 12/2015 A. Schroeter, I. A. M. Groh, G. Del Favero, M. Pignitter, K. Schueller, V. Somoza, D. Marko Inhibition of topoisomerase II by phase II metabolites of RSV in human colon cancer cells. Molecular Nutrition & Food Research

• 09/2015 Lanzicher T., Martinelli V., Puzzi L., Del Favero G., Codan B., Long CS., Mestroni L., Taylor MR., Sbaizero O. The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Scientific Reports

• 08/2015 T. Lanzicher, V. Martinelli, C. S. Long, G. Del Favero, L. Puzzi, M. Borelli, L. Mestroni, M. R.G. Taylor, O. Sbaizero, AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus

• 04/2015 O. Sbaizero, G. Del Favero, V. Martinelli, C.S. Long, L. Mestroni: Analysis of long- and short-range contribution to adhesion work in cardiac fibroblasts: An atomic force microscopy study. Materials Science and Engineering

• 03/2014 Del Favero G., Sosa S., Poli M., Tubaro A., Sbaizero O., Lorenzon P: In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: structural and functional impairment, Toxicology Letters

• 04/2014 B. Codan, G. Del Favero, V. Martinelli, C.S. Long, L. Mestroni, O. Sbaizero. Exploring the elasticity and adhesion behaviour of cardiac fibroblasts  by atomic force microscopy indentation. Materials Science and Engineering

• 06/2013 Del Favero G., Beltramo D., Sciancalepore M., Lorenzon P., Coslovich T., Poli M., Testai E., Sosa S., Tubaro A. Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes. Toxicon.

Oral Presentations (selection)

• Del Favero G., Bergen J., Iriarte-Mesa C., Jobst M., Crudo F., Marko D., Kleitz F., Berthiller F.: "4D model for intestinal toxicity profiling: a case study on Fusarium mycotoxins fumonisin B1 and deoxynivalenol", 45. Mycotoxin Workshop, 3.-5. June, 2024, Vienna, Austria

• 02/2024 Del Favero G.: "Bladder cells: morpho-metabolic adaption strategies to cope with chemical and physical challenges", Invited Talk at the XXXII Workshop of the Unit of Physiology and Biophysics at the University of Veterinary Medicine, Vienna, Austria

• 06/2023 Del Favero G., Jobst M., Gruber L., Hladuvka J., Gerner C.: "Unraveling the secrets of cell motility: from images to -omics with the help of bioinformatics", Invited talk at the Visegrad symposium on biomolecular interactions, Sopron, Hungary

• 02/02023 Del Favero G.: “Neue Perspektiven für die pharmakotoxikologische Analyse mit dem Ansatz der biophysikalischen Toxikologie”, Invited Talk at the Justus Liebig Universität, Gießen, Germany

• 02/2023 Del Favero G.: “Toxicity of urinary-occurring contaminants and mechanisms of adaptive plasticity of bladder cells”, Invited Talk at the INRAE, Toulouse, France

• 12/2022 Del Favero G.: Moving perspectives: physical and chemical signaling in the intestinal compartment, Invited talk at the Institute of Biophysics of the Czech Academy of Sciences, Brünn, Czech Republic

• 10/2022 Del Favero G., Activity profiling of Fusarium mycotoxins: new meachanisms for old enemies, Invited Talk at the World Congress of the International Society on Toxinology (IST), Abu Dhabi, United Arab Emirates

• 09/2022 Del Favero G., Toxicity triggered by modulation of mass and strucutral integrity of non-cytosekeletal organelles: a new perspective for organ-on-a-chip expermiments?, ASTOX Sympsoium, Vienna, Austria

• 11/2021 Del Favero G., Targeting membrane structure in intestinal cells: implications for biomechanical compliance and toxicity, ASTOX Mini-Symposium "Young Toxicologists", Online

• 02/2020 Del Favero G., Moving perspectives: bridging multi-imaging to multi-omics, 31st MassSpec Forum Vienna 2020, Vienna, Austria

• 12/2019 Del Favero G., Novel strategies for toxicity testing of food contaminants: the integrated biophysical toxicology approach, Invited talk at the Technical University of Berlin, Berlin, Germany

• 05/2019 Del Favero G., Janker L., Neuditschko B., Hohenbichler J., Woelfingseder L., Gerner Ch., Marko D., Proteomic profiling reveals molecular cell responses to deoxynivalenol treatment in human A431 epidermoid squamous carcinoma cells, 41. Mycotoxin Workshop, Lissabon, Portugal

• 04/2019 Del Favero G., Hohenbichler J., Mayer R.M., Zaharescu R., Marko D., Cell Membrane: structure and biophysical properties determining response to toxicants, ASTOX Symposium, Vienna, Austria

• 09/2018 Del Favero G., Marko D., Nrf2 and the intestine: chemical and physical regulators to highlight the difference between non-transformed intestinal epithelial cells and colorectal adenocarcinoma, Congress Bio2018, NutRedOx COST Action CA16112, Gdansk, Poland

• 07/2018 Del Favero G., Janker L., Neuditschko B., Woelflingseder L., Gerner Ch., Marko D., Unravelling the effect of deoxynivalenol on A431 cells: Proteome profiling and imaging, Mycotoxin Summer Talks, Tulln, Vienna
  

• 05/2018 Del Favero G., Woelflingseder L., Janker L., Neuditschko B., Gerner Ch., Marko D.,Image analysis and proteomic profiling: complementary tools for toxicity studies, Young Analytical Forum, Vienna, Austria

• 11/2017 Del Favero G., From microscopy to numbers: the long way of image analysis, Seminar of the Department of Analytical Chemistry, Vienna, Austria

• 07/2017 Del Favero G., Mycotoxins and mechanotransduction: A meeting at cellular level, Mycotoxin Summer Talks, Tulln, Austria

• 04/2017 Del Favero G., Woelflingseder L., Seriani S., Gallina P., Sbaizero O., Marko D. Characterization of the toxicity of deoxynivalenol in a mechanically stimulated environment, Astox Symposium, Vienna, Austria

• 05/2016 Del Favero G., Woelflingseder L., Pahlke G., Warth B., Fruhmann Ph., Krska R., Schuhmacher R., Wiesenberger G., Adam G., Marko D. Deoxynivalenol sulfates: detoxification metabolites? 38th Mycotoxin Workshop, Berlin, Germany