Francesco Crudo

Academic Career and Education

• Since 03/2021 PostDoc at the University of Vienna, Department of Food Chemistry and Toxicology. Research group: Prof. Dr. Doris Marko

• 08/2018-03/2020 Visiting PhD student at the University of Vienna, Department of Food Chemistry and Toxicology

• 11/2017-01/2021 PhD in Food Sciences, University of Parma, Italy. PhD thesis: "A toxicological evaluation of the interactions between Alternaria mycotoxins, food constituents and gut microbiota: implications for human health"

• 03/2017-09/2017 Postgraduate internship at the "Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna", Department of Microbiology and nucleic acids-based technology applied to food, Brescia, Italy

• 09/2016 State examination to practice the profession of biologist, University of Calabria, Italy

• 10/2013-03/2016 Master's degree in Nutritional Science, University of Calabria, Italy. Thesis title: "Geographical characterization of Sicilian monovarietal olive oils by ICP-MS analysis of trace elements"

• 09/2008-10/2013 Bachelor's degree in Nutritional Science, University of Calabria, Italy

Publications

• 02/2024 Crudo F., Dellafiora L., Hong Ch., Burger L., Jobst M., Del Favero G., Marko D., Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways, Toxicology Letters

• 12/2023 Louro H., Vettorazzi A., López de Cerain A., Spyropoulou A., Solhaug A., Straumfors A., Behr A-C., Mertens B., Žegura B., Kruse Fæste C., Ndiaye D., Spilioti E., Varga E., Dubreil E., Borsos E., Crudo F., Sundstøl Eriksen G., Snapkow I., Henri J.  11 , Sanders J.  6 , Machera K. 3 , Gaté L., Le Hegarat L., Novak M., Smith  N.M., Krapf S., Hager S., Fessard V., Kohl Y., Silva M.J., Dirven H., Dietrich J., Marko D., Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health, Archives of Toxicology

• 11/2023 Crudo F., Hong Ch., Varga E., Del Favero G., Marko D., Genotoxic and Mutagenic Effects of the Alternaria Mycotoxin Alternariol in Combination with the Process Contaminant Acrylamide, Toxins

• 07/2023 Iriarte-Mesa C., Jobst M. Bergen J., Kiss E., Ryoo R., Kim J.-C., Crudo F., Marko D., Kleitz F., Del Favero G., Morphology-Dependent Interaction of Silica Nanoparticles with Intestinal Cells: Connecting Shape to Barrier Function, Nano Letters

• 11/2022 Rabaaoui A., Masiello M., Somma S., Crudo F., Dall’Asta Ch., Righetti L., Susca A., Logrieco A.F., Namsi A., Gdoura R., Werbrouck S.P.O., Moretti A., Phylogeny and mycotoxin profiles of pathogenic Alternaria and Curvularia species isolated from date palm in southern Tunisia, Frontiers in Microbiology

• 04/2022 Crudo F., Aichinger G., Dellafiora L., Kiss E., Mihajlovic J., Del Favero G., Berry D., Dall’Asta Ch., Marko D., Persistence of the antagonistic effects of a natural mixture of Alternaria mycotoxins on the estrogen-like activity of human feces after anaerobic incubation, Toxicology Letters

• 01/2022 Aichinger G., Grgic D., Beisl J., Crudo F., Warth B., Varga E., Marko D., N-acetyl cysteine alters the genotoxic and estrogenic properties of Alternaria toxins in naturally occurring mixtures, Emerging Contaminants

• 04/2021 Crudo F., Aichinger G., Mihajlovic J., Varga E., Dellafiora L., Warth B., Dall'Asta Ch., Berry D., Marko D., In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship, Archives of Toxicology

• 04/2021 Crudo F., Barilli A., Mena P., Maria B., Del Rio D., Dall'Asta C. Dellafiora, L., An in vitro study on the transport and phase II metabolism of the mycotoxin alternariol in combination with the structurally related gut microbial metabolite urolithin C, Toxicology Letters

• 11/2020 Aichinger G., Živná N., Varga E., Crudo F., Warth B., Marko D., Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins, Mycotoxin Research

• 10/2020 Crudo F., Aichinger G., Mihajlovic J., Dellafiora L., Varga E., Puntscher H., Warth B., Dall'Asta C., Berry D., Marko D., Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro, Archives of Toxicology

• 11/2019 Crudo F., Varga E., Aichinger G., Galaverna G., Marko D., Dall'Asta C., Dellafiora L., Co-Occurrence and Combinatory Effects of Alternaria Mycotoxins and Other Xenobiotics of Food Origin: Current Scenario and Future Perspectives, Toxins (Basel)

Poster Presentations

• 09/2022 Crudo F., Hong Chenyifan, Del Favero G., Dellafiora L., Marko D., The Alternaria mycotoxin alternariol suppressess the DNA damage-induced phosphorylation of the histone H2AX, ASTOX Symposium, Vienna, Austria

• 11/2019 Crudo F., Aichinger G., Mihajlovic J., Dall’Asta C., Berry D., Marko D., The effects of fecal incubation on the genotoxic properties of a complex extract of Alternaria mycotoxins, 6^th Theodor Escherich Symposium, Medical University of Graz, Graz, Austria

Oral Presentations

• 06/2023 Crudo F., Hong C., Partsch V., Del Favero G., Dellafiora L., Marko D.: "New challenges in genotoxicity testing: the case of the Alternaria mycotoxins alternariol and altertoxin II", Talk at the 44. Mycotoxin Workshop, Celle, Germany

• 05/2022 Crudo F., Aichinger G., Varga E., Dellafiora L., Warth B., Berry D., Dall´Astra C., Marko D., The bidirectional relationship between Alternaria mycotoxins and the gut microbiota, World Mycotoxin Forum, Parma, Italy

• 04/2022 Crudo F., Human gut bacterial strains and Alternaria mycotoxins: effects of interactions on mycotoxin bioavailability and bacterial growth, "Österreichische Lebensmittelchemikertage", Online

• 05/2021 Crudo F., Aichinger G., Mihajlovic J., Varga E., Dellafiora L., Warth B. Dall´Asta Ch., Berry D., Marko D., In vitro interactions of Alternaria mycotoxins with the gut microbiota: a birectional relationship, 42. Mycotoxin Workshop, Online

Awards

• 2022 Second Poster Prize: "The Alternaria mycotoxin alternariol suppresses the DNA damage-induced phosphorylation of the histone H2AX", ASTOX Symposium, Sept. 15-16, 2022, BOKU, Vienna Austria